在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-HCLS1 (Y378) Antibody

Phospho-HCLS1 (Y378) Antibody

  • 中文名稱：
    磷酸化-HCLS1 (Y378)兔多克隆抗體
  • 貨號：
    CSB-PA009133
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    HCLS1
  • 別名：
    Cortactin like antibody; CTTNL antibody; HCLS 1 antibody; Hcls1 antibody; HCLS1_HUMAN antibody; Hematopoietic cell specific Lyn substrate 1 antibody; Hematopoietic cell-specific LYN substrate 1 antibody; Hematopoietic lineage cell-specific protein antibody; HS 1 antibody; HS1 antibody; LckBP1 antibody; OTTHUMP00000215180 antibody; OTTHUMP00000215182 antibody; p75 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from Human Lck BP-1 around the phosphorylation site of Y378.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
  • 基因功能參考文獻：
    1. these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
    2. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
    3. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
    4. interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
    5. HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
    6. a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
    7. High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
    8. SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
    9. HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
    10. substrate for caspase cleavage during apoptosis PMID: 11689006
    11. TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
    12. found in cell types other than hematopoietic cells PMID: 15754022
    13. HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
    14. The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
    15. HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
  • 組織特異性：
    Expressed only in tissues and cells of hematopoietic origin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4844

    OMIM: 601306

    KEGG: hsa:3059

    STRING: 9606.ENSP00000320176

    UniGene: Hs.14601



主站蜘蛛池模板： 全部av―极品视觉盛宴| 强行无套内谢大学生初次| 性久久久久久久| 免费超爽大片黄| 亚洲精品久久久一二三区| 无码国产片观看| 亚洲第一a在线观看网站| 中文字幕一精品亚洲无线一区| 久久亚洲精品11p| 亚洲欧洲成人av每日更新| 亚洲中文有码字幕日本第一页| 日本日本熟妇中文在线视频| 少妇无码太爽了不卡视频在线看| 亚洲精品～无码抽插| 性夜影院午夜看片| 精品亚洲卡一卡2卡三卡乱码| 加勒比色综合久久久久久久久 | 国产熟妇人妻精品一区二区动漫 | 国产成人无码一区二区在线观看| 尤物视频在线观看| 一本大道一卡2卡三卡4卡国产| 国产福利一区二区麻豆| 久久久久人妻精品一区三寸蜜桃| 99精品国产兔费观看久久99| 欧美成aⅴ人高清怡红院| 亚洲精品久久久久中文字幕m男| 无码专区一va亚洲v专区在线 | 人人玩人人添人人澡| 亚洲精品国产一二三无码av| 午夜天堂一区人妻| 麻豆av一区二区三区久久| 日韩精品无码免费一区二区三区 | 国产精品久久无码不卡| 秋霞在线观看片无码免费不卡| 亚洲中文字幕无码永久在线不卡| а√天堂www在线天堂小说| 日本又色又爽又黄的视频免| 邪恶肉肉全彩色无遮盖| 加勒比久久综合网天天| 免费毛片a线观看| 国产亚洲精品自在久久蜜tv|