在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-HCLS1 (Tyr397) Antibody

  • 中文名稱:
    磷酸化-HCLS1 (Tyr397)兔多克隆抗體
  • 貨號:
    CSB-PA258754
  • 規(guī)格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from JK cells (Lane 2), using HS1 (Phospho-Tyr397) Antibody.The lane on the left is treated with antigen-specific peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HCLS1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HCLS1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence around phosphorylation site of tyrosine 397(G-D-Y(p)-E-E) derived from Human HS1 .
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
  • 基因功能參考文獻:
    1. these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
    2. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
    3. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
    4. interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
    5. HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
    6. a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
    7. High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
    8. SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
    9. HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
    10. substrate for caspase cleavage during apoptosis PMID: 11689006
    11. TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
    12. found in cell types other than hematopoietic cells PMID: 15754022
    13. HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
    14. The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
    15. HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
  • 組織特異性:
    Expressed only in tissues and cells of hematopoietic origin.
  • 數據庫鏈接:

    HGNC: 4844

    OMIM: 601306

    KEGG: hsa:3059

    STRING: 9606.ENSP00000320176

    UniGene: Hs.14601



主站蜘蛛池模板: 伊伊综合在线视频无码| 国产啪视频1000部免费| 日韩国产成人无码av毛片蜜柚| 免费国产精品视频在线| 久久天天躁狠狠躁夜夜96流白浆 | 亚洲精品国产精华液有哪些| 男女啪啪抽搐呻吟高潮动态图| 国产高清在线精品一区免费| 日日摸日日碰人妻无码老牲| 法国啄木乌av片在线播放| 大香线蕉伊人超碰| 伊伊人成亚洲综合人网| 色欲aⅴ 无码| 无尺码精品产品网站| 国产综合久久久久| 久久精品国产99久久香蕉| 国内偷窥一区二区三区视频| 午夜精品乱人伦小说区| 日韩成av人片在线观看| 亚洲精品色无码av试看| 99久久精品费精品国产一区二| 国产毛片久久久久久国产毛片| 男人的天堂av网站| 国产亚洲香蕉线播放αv38| 人妻少妇无码专视频在线| 欧美性猛交xxxx乱大交3| 国产对白老熟女正在播放| 欧美激情乱人伦| 久久人人超碰精品caoporen| 在线观看午夜亚洲一区| 日本大尺度吃奶呻吟视频| 国产在线拍偷自揄拍无码| 亚洲gv永久无码天堂网| 欧美两根一起进3p在线观看| 人妻体内射精一区二区三区 | 久久精品人妻无码一区二区三区v| 久久久国产99久久国产久一| 东京无码熟妇人妻av在线网址| 激情毛片无码专区| 成人麻豆亚洲综合无码精品| 国产成人无码精品久久久露脸|