在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-EIF4B (Ser422) Antibody

  • 中文名稱:
    磷酸化-EIF4B (Ser422)兔多克隆抗體
  • 貨號(hào):
    CSB-PA696997
  • 規(guī)格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from Hela cells untreated or treated with EGF using eIF4B(phospho-Ser422) Antibody.
    • Immunohistochemical analysis of paraffin-embedded human lung carcinomatissue using eIF4B(Phospho-Ser422) Antibody(left) or the same antibody preincubated with blocking peptide(right).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) EIF4B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Peptide sequence around phosphorylation site of Serine 422 (T-G-S(p)-E-S) derived from Human eIF4B.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:50-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
  • 基因功能參考文獻(xiàn):
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. PMID: 27528663
    3. Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. PMID: 27773818
    4. Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. PMID: 26848623
    5. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. PMID: 25955794
    6. S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. PMID: 25220053
    7. eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. PMID: 24205356
    8. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. PMID: 24829357
    9. eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL PMID: 24135829
    10. Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
    11. Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. PMID: 23813671
    12. our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes PMID: 23749639
    13. ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. PMID: 21994950
    14. The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding. PMID: 12885229
    15. eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation PMID: 15071500
    16. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    17. Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. PMID: 16763566
    18. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

    顯示更多

    收起更多

  • 數(shù)據(jù)庫鏈接:

    HGNC: 3285

    OMIM: 603928

    KEGG: hsa:1975

    STRING: 9606.ENSP00000262056

    UniGene: Hs.648394



主站蜘蛛池模板: 久久综合久久美利坚合众国| 国产裸拍裸体视频在线观看| 色插图午夜影院| 午夜寂寞少妇aaa片毛片| 狠狠躁夜夜躁人人躁婷婷| 天天躁久久躁日日躁| 人妻av无码中文专区久久| 熟妇与小伙子matur老熟妇e| 中文在线а√在线| 久久九九兔免费精品6| 日韩在线看片免费人成视频播放 | 人妻激情文学| 永久免费的av在线电影网无码| 亚洲精品卡2卡3卡4卡5卡区| 国产一区丝袜高跟鞋| 免费网站观看www在线观看| 国产69精品久久久久999小说| 久久精品国产久精国产一老狼| 久久精品亚洲乱码伦伦中文 | 一二三四在线视频社区3| 久久婷婷五月综合色一区二区 | 99国产成人精品视频| 浓毛欧美老妇乱子伦视频| 国产成年无码久久久久下载| 四虎影视永久地址www成人| 午夜性色福利在线观看视频| 成人免费无码不卡毛片视频| 无码人妻av免费一区二区三区| 女人被狂躁到高潮视频免费软件 | 国产狂喷潮在线观看中文| 亚洲午夜无码av毛片久久| 国产后进白嫩翘臀在线播放| 欧美激烈精交gif动态图| 内射人妻少妇无码一本一道 | 亚洲国产精品无码观看久久| 欧美日韩午夜群交多人轮换| 成人视频在线观看| 欧美色偷偷亚洲天堂bt| 色噜噜狠狠色综合av| 欧美成人精品第一区二区三区 | 国产欧美熟妇另类久久久|