在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-EIF4B (S422) Antibody

  • 中文名稱:
    磷酸化-EIF4B (S422)兔多克隆抗體
  • 貨號(hào):
    CSB-PA011284
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Phospho-eIF4B (S422) Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2310046H11Rik antibody; AL024095 antibody; C85189 antibody; EIF 4B antibody; eIF-4B antibody; EIF4B antibody; Eukaryotic initiation factor 4B antibody; Eukaryotic translation initiation factor 4B antibody; IF4B_HUMAN antibody; PRO1843 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human eIF4B around the phosphorylation site of S422.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
  • 基因功能參考文獻(xiàn):
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. PMID: 27528663
    3. Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. PMID: 27773818
    4. Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. PMID: 26848623
    5. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. PMID: 25955794
    6. S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. PMID: 25220053
    7. eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. PMID: 24205356
    8. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. PMID: 24829357
    9. eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL PMID: 24135829
    10. Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
    11. Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. PMID: 23813671
    12. our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes PMID: 23749639
    13. ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. PMID: 21994950
    14. The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding. PMID: 12885229
    15. eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation PMID: 15071500
    16. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    17. Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. PMID: 16763566
    18. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

    顯示更多

    收起更多

  • 數(shù)據(jù)庫鏈接:

    HGNC: 3285

    OMIM: 603928

    KEGG: hsa:1975

    STRING: 9606.ENSP00000262056

    UniGene: Hs.648394



主站蜘蛛池模板: 国产 | 欧洲野花视频欧洲1| 四虎亚洲中文字幕无码永久 | 啪啪激情婷婷久久婷婷色五月| 综合久久—本道中文字幕| 欧美黑人激情性久久| 人人妻人人澡人人爽不卡视频| 老熟妇仑乱视频一区二区| 亚洲国产精品综合久久网各| 婷婷网亚洲色偷偷男人的天堂| 手机在线亚洲国产精品| 五十路丰满中年熟女中出 | 亚洲熟女av乱码在线观看漫画| 国产精品无码久久久久久| 久久丫精品久久丫| 亚洲欧美一区二区三区在线| 国产成人欧美亚洲日韩电影| 开心色婷婷色五月激情| 无码喷水一区二区浪潮av| 久久精品久久精品久久39| 亚洲 日韩 欧美 成人 在线观看| 在线观看免费视频污网站| 国产无遮挡色视频免费观看性色| 国产精品日本亚洲欧美| 国产人妻777人伦精品hd| 国产精品无码无在线观看| 免费国产白丝喷水娇喘视频| 亚洲精品av一区在线观看| 把插八插露脸对白内射| 国产精品天干天干有线观看 | 国产女人的高潮国语对白| 中国xxxx做受视频| 精品日韩亚洲欧美高清a| 成年午夜无码av片在线观看| 欧美成人精品第一区二区三区| 国产精品毛片完整版视频| 亚洲色欲在线播放一区| 日韩国产综合精选| 亚洲国产精品成人无码区| 中文字幕亚洲无线码一区女同| 永久免费精品成人网站| 久久无码高潮喷水|