在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF4B Antibody, Biotin conjugated

  • 中文名稱:
    EIF4B兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA007554LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EIF4B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    2310046H11Rik antibody; AL024095 antibody; C85189 antibody; EIF 4B antibody; eIF-4B antibody; EIF4B antibody; Eukaryotic initiation factor 4B antibody; Eukaryotic translation initiation factor 4B antibody; IF4B_HUMAN antibody; PRO1843 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic translation initiation factor 4B protein (362-590AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
  • 基因功能參考文獻:
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. PMID: 27528663
    3. Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. PMID: 27773818
    4. Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. PMID: 26848623
    5. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. PMID: 25955794
    6. S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. PMID: 25220053
    7. eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. PMID: 24205356
    8. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. PMID: 24829357
    9. eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL PMID: 24135829
    10. Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
    11. Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. PMID: 23813671
    12. our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes PMID: 23749639
    13. ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. PMID: 21994950
    14. The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding. PMID: 12885229
    15. eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation PMID: 15071500
    16. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    17. Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. PMID: 16763566
    18. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

    顯示更多

    收起更多

  • 數據庫鏈接:

    HGNC: 3285

    OMIM: 603928

    KEGG: hsa:1975

    STRING: 9606.ENSP00000262056

    UniGene: Hs.648394



主站蜘蛛池模板: 国产成人免费爽爽爽视频| 大陆极品少妇内射aaaaa| 无遮挡又黄又刺激的视频| 日本免费人成视频播放| 美女扒开奶罩露出奶头视频网站| 国产精品无码久久四虎| 无码成人精品区在线观看| 一二三四在线观看免费视频| 成人无码a片一区二区三区免| 综合欧美日韩国产成人| 手机真实国产乱子伦对白视频| 欧美与黑人午夜性猛交久久久| 国产一区二区三区| 成人片黄网站a毛片免费观看| 久久精品一本到东京热| 99精品国产免费观看视频| 无翼乌工口肉肉无遮挡无码18| 日本人妻中文字幕乱码系列| 2021久久国自产拍精品| 亚洲va中文字幕无码毛片| 解开人妻的裙子猛烈进入| 亚洲国产欧美在线人成人| 夜夜天天噜狠狠爱2019| 中文字幕高清免费日韩视频在线 | а√天堂8资源在线官网| 国产特级毛片aaaaaa高潮流水 | 亚洲 另类 日韩 制服 无码| 别揉我奶头~嗯~啊~一区二区三区| 九九热爱视频精品视频| 国产精品日韩av在线播放| 忘忧草日本在线播放www| 国产乱子伦60女人的皮视频 | 国内少妇高潮嗷嗷叫在线播放| 亚洲综合久久一区二区| 日韩av高清无码| 国产亚洲精选美女久久久久 | 亚洲国产成人高清影视 | 亚洲熟妇无码av在线播放| 亚洲欧美在线人成最新| 国产成人免费高清直播| 国产农村老太xxxxhdxx|