在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPH Antibody

  • 中文名稱:
    PRPH兔多克隆抗體
  • 貨號:
    CSB-PA018774GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PRPH
  • 別名:
    NEF 4 antibody; NEF4 antibody; Neurofilament 4 (57kD) antibody; Neurofilament 4 antibody; Perf antibody; PERI_HUMAN antibody; Peripherin antibody; PRPH 1 antibody; prph antibody; PRPH1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PRPH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea.
  • 基因功能參考文獻:
    1. Desmin, Glial Fibrillary Acidic Protein, Vimentin, and Peripherin are type III intermediate filaments that have roles in health and disease [review] PMID: 29196434
    2. To discover of Phosphorylated autoantigens Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus. PMID: 27185639
    3. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones PMID: 26469323
    4. interaction between disease-causing RAB7A mutants and peripherin could play an important role in Charcot-Marie-Tooth type 2B neuropathy PMID: 23179371
    5. This work contributes to determine the role of PRPH gene variants in ALS. Further studies are necessary to define the mechanisms through which the mutant peripherin could cause ALS phenotype. PMID: 20363051
    6. study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP PMID: 21088854
    7. although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions PMID: 21241994
    8. Transgenic peripherin isoform expression reveals post-transcriptional changes to the normal expression pattern associated with malformed filaments and intracellular inclusions underlying a role in the pathogenesis of amyotrophic lateral sclerosis. PMID: 20533992
    9. The data of this experiment document the expression of peripherin in Lewy body-like inclusions , which may provide a clue to the pathogenesis of neurodegeneration in ALS. PMID: 14675609
    10. Peripherin overexpression in transgenic mice can cause defective transport of type IV neurofilament proteins, a phenomenon that may account for the progressive formation of amyotrophic lateral sclerosis-like spheroids in axons. PMID: 16787413
    11. peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration PMID: 17569669
    12. Peripherin splicing abnormalities occur in amyotrophic lateral sclerosis generating aggregation-prone splice isoforms, one of which causes peripherin aggregation when its expression is upregulated. PMID: 18287500
    13. Expression of the 2 markers, peripherin and alpha-internexin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
    14. Transgenic mice expressing the PRPH-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence. PMID: 18709437

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells.
  • 數據庫鏈接:

    HGNC: 9461

    OMIM: 170710

    KEGG: hsa:5630

    STRING: 9606.ENSP00000257860

    UniGene: Hs.37044



主站蜘蛛池模板: 久久国产精品偷| 久久精品国产亚洲αv忘忧草| 暖暖视频日本| 亚洲已满18点击进入在线看片| 亚洲欧美韩国综合色| 欧美性群另类交| 男人靠女人的免费视频| 无码粉嫩虎白一线天在线观看| 丝袜人妻一区二区三区| 精品一卡二卡三卡四卡网站| 亚洲色无码专区在线观看| 久久久久99精品成人片三人毛片| 50岁退休熟女露脸高潮| 色老99久久九九爱精品| 久久99九九精品久久久久蜜桃| 激情综合婷婷丁香五月| 一边摸一边做爽的视频17国产| 中文字幕中文有码在线| 人妻在线无码一区二区三区| 中文字幕亚洲无线码在线一区| 少妇无码av无码专区线| 久欠精品国国产99国产精2021| 日日摸日日碰夜夜爽av| 亚洲精品久久久久久一区二区| 中文字幕一二三区波多野结衣 | www插插插无码视频网站| 在线偷着国产精选视频| 免费无码午夜理论电影| 少妇扒开粉嫩小泬视频| 欧美xxxx做受欧美1314 | 亚洲欧美另类成人综合图片| 高清国产av一区二区三区| 久久精品免费一区二区三区 | 亚洲精品一区二区三区婷婷月| 日日婷婷夜日日天干| 99久久久无码国产精品免费砚床 | 99久久综合狠狠综合久久| 十八禁无码精品a∨在线观看| 少妇的丰满人妻hd高清| 亚洲人亚洲精品成人网站| 无码少妇一区二区浪潮免费|