在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPH Antibody

  • 中文名稱:
    PRPH兔多克隆抗體
  • 貨號:
    CSB-PA018774ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA018774ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018774ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRPH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRPH
  • 別名:
    NEF 4 antibody; NEF4 antibody; Neurofilament 4 (57kD) antibody; Neurofilament 4 antibody; Perf antibody; PERI_HUMAN antibody; Peripherin antibody; PRPH 1 antibody; prph antibody; PRPH1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peripherin protein (1-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea.
  • 基因功能參考文獻:
    1. Desmin, Glial Fibrillary Acidic Protein, Vimentin, and Peripherin are type III intermediate filaments that have roles in health and disease [review] PMID: 29196434
    2. To discover of Phosphorylated autoantigens Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus. PMID: 27185639
    3. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones PMID: 26469323
    4. interaction between disease-causing RAB7A mutants and peripherin could play an important role in Charcot-Marie-Tooth type 2B neuropathy PMID: 23179371
    5. This work contributes to determine the role of PRPH gene variants in ALS. Further studies are necessary to define the mechanisms through which the mutant peripherin could cause ALS phenotype. PMID: 20363051
    6. study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP PMID: 21088854
    7. although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions PMID: 21241994
    8. Transgenic peripherin isoform expression reveals post-transcriptional changes to the normal expression pattern associated with malformed filaments and intracellular inclusions underlying a role in the pathogenesis of amyotrophic lateral sclerosis. PMID: 20533992
    9. The data of this experiment document the expression of peripherin in Lewy body-like inclusions , which may provide a clue to the pathogenesis of neurodegeneration in ALS. PMID: 14675609
    10. Peripherin overexpression in transgenic mice can cause defective transport of type IV neurofilament proteins, a phenomenon that may account for the progressive formation of amyotrophic lateral sclerosis-like spheroids in axons. PMID: 16787413
    11. peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration PMID: 17569669
    12. Peripherin splicing abnormalities occur in amyotrophic lateral sclerosis generating aggregation-prone splice isoforms, one of which causes peripherin aggregation when its expression is upregulated. PMID: 18287500
    13. Expression of the 2 markers, peripherin and alpha-internexin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
    14. Transgenic mice expressing the PRPH-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence. PMID: 18709437

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells.
  • 數據庫鏈接:

    HGNC: 9461

    OMIM: 170710

    KEGG: hsa:5630

    STRING: 9606.ENSP00000257860

    UniGene: Hs.37044



主站蜘蛛池模板: 自拍区小说区图片区亚洲| 国产真人做爰毛片视频直播| 国产成人无码精品午夜福利a| 99热这里有精品| 99久久99久久久精品齐齐综合色圆| 国产精品亚洲玖玖玖在线观看| 极品人妻少妇一区二区三区| 国产精品久久久久久久久免费| 狠狠亚洲婷婷综合色香五月排名| 国产午夜精华2020在线| 四虎影库久免费视频| 精品久久香蕉国产线看观看亚洲| 日日摸天天摸爽爽狠狠97| 无码国产激情在线观看| 国产成人综合久久免费| 大肉大捧一进一出好爽| 欧美精品18videosex性欧美 | 日韩爆乳一区二区无码| 中国猛少妇色xxxxx| 免费人成视频在线播放| 无码一区二区波多野结衣播放搜索| 国产高清乱码又大又圆| 国产一区二区三区不卡在线看| 无码国产精品一区二区免费模式 | 少妇无套内谢久久久久| 最新国产久免费视频在线观看 | 欧美成人在线视频| 日韩无套内射视频6| 无码人妻专区免费视频| 国产精品v片在线观看不卡| 国产精品爆乳在线播放第一人称 | 亚洲精品一区二区三区在线观看| 大屁股熟女白浆一区二区| 色偷偷女人的天堂亚洲网| 欧美丰满熟妇bbbbbb百度| 国产精品久久久国产盗摄| 国产免费爽爽视频在线观看| 亚洲精品久久久口爆吞精| 久无码久无码av无码| 色猫咪免费人成网站在线观看| 萝卜视频高清免费视频日本|