在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRPH Antibody

  • 中文名稱:
    PRPH兔多克隆抗體
  • 貨號:
    CSB-PA018774ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA018774ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRPH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRPH
  • 別名:
    NEF 4 antibody; NEF4 antibody; Neurofilament 4 (57kD) antibody; Neurofilament 4 antibody; Perf antibody; PERI_HUMAN antibody; Peripherin antibody; PRPH 1 antibody; prph antibody; PRPH1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peripherin protein (1-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea.
  • 基因功能參考文獻:
    1. Desmin, Glial Fibrillary Acidic Protein, Vimentin, and Peripherin are type III intermediate filaments that have roles in health and disease [review] PMID: 29196434
    2. To discover of Phosphorylated autoantigens Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus. PMID: 27185639
    3. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones PMID: 26469323
    4. interaction between disease-causing RAB7A mutants and peripherin could play an important role in Charcot-Marie-Tooth type 2B neuropathy PMID: 23179371
    5. This work contributes to determine the role of PRPH gene variants in ALS. Further studies are necessary to define the mechanisms through which the mutant peripherin could cause ALS phenotype. PMID: 20363051
    6. study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP PMID: 21088854
    7. although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions PMID: 21241994
    8. Transgenic peripherin isoform expression reveals post-transcriptional changes to the normal expression pattern associated with malformed filaments and intracellular inclusions underlying a role in the pathogenesis of amyotrophic lateral sclerosis. PMID: 20533992
    9. The data of this experiment document the expression of peripherin in Lewy body-like inclusions , which may provide a clue to the pathogenesis of neurodegeneration in ALS. PMID: 14675609
    10. Peripherin overexpression in transgenic mice can cause defective transport of type IV neurofilament proteins, a phenomenon that may account for the progressive formation of amyotrophic lateral sclerosis-like spheroids in axons. PMID: 16787413
    11. peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration PMID: 17569669
    12. Peripherin splicing abnormalities occur in amyotrophic lateral sclerosis generating aggregation-prone splice isoforms, one of which causes peripherin aggregation when its expression is upregulated. PMID: 18287500
    13. Expression of the 2 markers, peripherin and alpha-internexin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
    14. Transgenic mice expressing the PRPH-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence. PMID: 18709437

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells.
  • 數據庫鏈接:

    HGNC: 9461

    OMIM: 170710

    KEGG: hsa:5630

    STRING: 9606.ENSP00000257860

    UniGene: Hs.37044



主站蜘蛛池模板: 国产 校园 另类 小说区| 日本成aⅴ人片日本伦| 日本欧美久久久久免费播放网 | 国产超碰无码最新上传| 日本高清二区视频久二区| 特级毛片a片久久久久久| 狠狠综合久久久久尤物丿| 精品无人区一区二区三区在线| 男女啪啪抽搐呻吟高潮动态图| 国产精品人妻久久久久| 99亚洲男女激情在线观看| 久久99精品国产麻豆蜜芽| 精品一区二区三区国产在线观看| 国内精品久久久久av福利秒拍| 五月丁香六月综合缴清无码| 99久久久无码国产精品古装 | 精品无码av不卡一区二区三区| 欧美人与善在线com| 性xxxx欧美老妇胖老太性多毛| 中文字幕乱码在线播放| 天天摸日日摸爽爽狠狠| 精品国产三级a在线观看网站| 青草青草视频2免费观看| 亚洲熟熟妇xxxx| 久久精品国产第一区二区三区| 精品国产电影久久九九| 免费三级网站| 欧美孕妇乳喷奶水在线观看| 久久亚洲精品国产精品777777| 色94色欧美sute亚洲线路一| 50岁熟妇大白屁股真爽| 青娱乐极品视觉盛宴国产视频 | 狠狠噜狠狠狠狠丁香五月| 一本一道久久a久久精品综合| 波多野结衣一区二区三区高清av| 欧洲无码精品a码无人区| 中文在线天堂а√在线| 高潮毛片又色又爽免费| av无码人妻一区二区三区牛牛| 国产精品青草久久久久福利99| 乱人伦人妻中文字幕无码久久网|