在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPME1 Antibody

PPME1 Antibody

  • 中文名稱：
    PPME1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA018501GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PPME1
  • 別名：
    PME 1 antibody; PME-1 antibody; PME1 antibody; PPME1 antibody; PPME1_HUMAN antibody; Protein phosphatase methylesterase 1 antibody; Testicular Secretory Protein Li 39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PPME1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
  • 基因功能參考文獻(xiàn)：
    1. Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. PMID: 30340029
    2. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). PMID: 27810903
    3. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. PMID: 27913678
    4. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. PMID: 27048286
    5. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division PMID: 25839665
    6. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. PMID: 24253382
    7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    8. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 PMID: 22732552
    9. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. PMID: 21398589
    10. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. PMID: 17803990
    11. Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. PMID: 19293187

    顯示更多

    收起更多

  • 蛋白家族：
    AB hydrolase superfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30178

    OMIM: 611117

    KEGG: hsa:51400

    STRING: 9606.ENSP00000329867

    UniGene: Hs.503251



主站蜘蛛池模板： 中文字幕在线不卡精品视频99| 午夜男女爽爽影院免费视频| 国产在线观看码高清视频| 精品欧美小视频在线观看| 色狠狠av一区二区三区| 无套内内射视频网站| 亚洲成av人片天堂网| 熟女人妻一区二区三区免费看| 亚洲精品国偷拍自产在线麻豆| 国产老太睡小伙子视频| 上司人妻互换hd无码| 日本在线高清不卡免费播放| 午夜免费啪视频| 国产熟妇按摩3p高潮大叫| 亚洲人成电影在线天堂色| 另类亚洲综合区图片小说区| 日产幕无线码三区在线| 中国女人做爰视频| 超薄肉色丝袜一区二区| 久久久久人妻一区精品果冻| 97国语精品自产拍在线观看| 久久香港三级台湾三级播放 | 精品久久久久久无码不卡| 久久婷婷五月综合97色一本一本| 国模杨依粉嫩蝴蝶150p| 亚洲一区二区三区中文字幕在线 | 天堂а√中文在线| 一边啪啪的一边呻吟声口述| 国产高清在线精品一区二区三区| 日日大香人伊一本线久| 一边做一边喷17p亚洲乱妇50p| 最新的国产成人精品2021| 亚洲成a人片在线观看无码下载| 亚洲精品亚洲人成在线| 18黄暴禁片在线观看| 久久97超碰色中文字幕总站| 综合欧美日韩国产成人| 成人无码α片在线观看不卡 | 国产精品永久免费| 中文字幕在线免费看线人| 护士被强女千到高潮视频|