在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPME1 Antibody

PPME1 Antibody

  • 中文名稱：
    PPME1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA018501GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PPME1
  • 別名：
    PME 1 antibody; PME-1 antibody; PME1 antibody; PPME1 antibody; PPME1_HUMAN antibody; Protein phosphatase methylesterase 1 antibody; Testicular Secretory Protein Li 39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PPME1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
  • 基因功能參考文獻(xiàn)：
    1. Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. PMID: 30340029
    2. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). PMID: 27810903
    3. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. PMID: 27913678
    4. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. PMID: 27048286
    5. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division PMID: 25839665
    6. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. PMID: 24253382
    7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    8. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 PMID: 22732552
    9. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. PMID: 21398589
    10. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. PMID: 17803990
    11. Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. PMID: 19293187

    顯示更多

    收起更多

  • 蛋白家族：
    AB hydrolase superfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30178

    OMIM: 611117

    KEGG: hsa:51400

    STRING: 9606.ENSP00000329867

    UniGene: Hs.503251



主站蜘蛛池模板： 日韩不卡1卡2卡三卡2021免费| 337p西西人体大胆瓣开下部| 久艹视频免费看| 亚洲欧洲无码av不卡在线| 污污网站18禁在线永久免费观看| 人妻av综合天堂一区| xx性欧美肥妇精品久久久久久| 精品人妻中文字幕有码在线| 男人的天堂av社区在线| 欧美40老熟妇色xxxxx| 国产精品亚洲一区二区| 韩产日产国产欧产| 免费无码成人av在线播| 久久精品av国产一区二区| 精品国产亚洲一区二区三区 | 欧美日韩亚洲精品瑜伽裤| 久久99国产综合精品免费| 亚洲欧美国产成人综合欲网| 亚洲综合电影小说图片区| 国产无遮挡又黄又爽网站| 丁香五月欧美成人| 欧美黑人欧美精品刺激| 国产无限次数成版人视频在线| 色午夜日本高清视频www| 无套内内射视频网站| 娇妻被黑人粗大高潮白浆| 久久亚洲国产最新网站之一| 亚洲中文在线精品国产| 国内最真实的xxxx人伦| 高h猛烈失禁潮喷无码视频| 西西人体大胆无码视频| 人妻熟女一区二区三区app下载| 午夜亚洲www湿好爽| 久久精品国产亚洲a片高清不卡| 国产超碰人人做人人爽av大片| 大白肥妇bbvbbw高潮| 三叶草欧洲码在线| 1区2区3区高清视频| 亚洲综合精品香蕉久久网| 无码人妻一区二区三区线| 大肉大捧一进一出好爽动态图 |