在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPME1 Antibody, HRP conjugated

PPME1 Antibody, HRP conjugated

  • 中文名稱：
    PPME1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA018501LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PPME1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PPME1
  • 別名：
    PME 1 antibody; PME-1 antibody; PME1 antibody; PPME1 antibody; PPME1_HUMAN antibody; Protein phosphatase methylesterase 1 antibody; Testicular Secretory Protein Li 39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein phosphatase methylesterase 1 protein (201-386AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
  • 基因功能參考文獻(xiàn)：
    1. Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. PMID: 30340029
    2. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). PMID: 27810903
    3. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. PMID: 27913678
    4. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. PMID: 27048286
    5. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division PMID: 25839665
    6. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. PMID: 24253382
    7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    8. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 PMID: 22732552
    9. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. PMID: 21398589
    10. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. PMID: 17803990
    11. Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. PMID: 19293187

    顯示更多

    收起更多

  • 蛋白家族：
    AB hydrolase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30178

    OMIM: 611117

    KEGG: hsa:51400

    STRING: 9606.ENSP00000329867

    UniGene: Hs.503251



主站蜘蛛池模板： av鲁丝一区鲁丝二区鲁丝三区| 亚洲精品国产一区二区精华| 国产精品美女乱子伦高潮| 中文字幕人妻丝袜乱一区三区| 国产精品人妻一区二区三区四 | 成人久久久久久久久久久| 日韩综合无码一区二区| 国产亚洲精品久久久性色情软件| 国产精品va在线观看老妇女| 亚洲人成人网站在线观看| 日本肥老妇色xxxxx日本老妇| 亚洲综合色自拍一区| 日本一区二区a√成人片| 国产福利在线永久视频| 中国女人高潮hd| 夜夜夜高潮夜夜爽夜夜爰爰| 精品国产av最大网站| 欧美在线观看免费专区| 伦伦影院午夜理论片| 99久久无色码中文字幕| 精品亚洲成a人片在线观看| 日本熟妇乱人伦a片免费高清| 扒开双腿吃奶呻吟做受视频| 国产 高潮 抽搐 正在播放 | 人妻无码中字在线a| 精品久久人人爽天天玩人人妻| 欧美高清精品一区二区| 无码人妻久久1区2区3区| 女人被男人躁得好爽免费视频| 国产精品兄妹在线观看麻豆| 国产成人无码a区在线| 久久精品国产亚洲不av麻豆 | 亚洲欧美日韩综合一区| 色欲av亚洲情无码av蜜桃| 亚洲国产无套无码av电影| 无码精品人妻一区二区三区漫画| 成人午夜看黄在线尤物成人| 亚洲色欲色欲www成人网| 国产精品偷窥熟女精品视频| 丰满人妻一区二区三区无码av| 被窝的午夜无码福利专区|