在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPME1 Antibody, FITC conjugated

  • 中文名稱:
    PPME1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA018501LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PPME1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PPME1
  • 別名:
    PME 1 antibody; PME-1 antibody; PME1 antibody; PPME1 antibody; PPME1_HUMAN antibody; Protein phosphatase methylesterase 1 antibody; Testicular Secretory Protein Li 39 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein phosphatase methylesterase 1 protein (201-386AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
  • 基因功能參考文獻:
    1. Authors found that PME-1 is exported from the nucleus to the cytoplasm upon H2O2 treatment and redistributes dem-p-PP2Ac in subcellular compartments. These findings offer new insight into the regulation of PME-1 localization and PP2A demethylation under oxidative stress. PMID: 30340029
    2. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK). PMID: 27810903
    3. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A) activity by highly complex mechanisms. PMID: 27913678
    4. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer. PMID: 27048286
    5. LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division PMID: 25839665
    6. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer. PMID: 24253382
    7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    8. GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 PMID: 22732552
    9. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. PMID: 21398589
    10. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. PMID: 17803990
    11. Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas. PMID: 19293187

    顯示更多

    收起更多

  • 蛋白家族:
    AB hydrolase superfamily
  • 數據庫鏈接:

    HGNC: 30178

    OMIM: 611117

    KEGG: hsa:51400

    STRING: 9606.ENSP00000329867

    UniGene: Hs.503251



主站蜘蛛池模板: 国产成人亚洲精品无码电影| 亚洲精品无播放器在线播放| 欧美日本韩国亚洲| 成熟老妇女视频| 日本道色综合久久影院| 久久www成人免费网站| 久久理论片午夜琪琪电影网| 国产精华av午夜在线| 一本大道东京热无码aⅴ| 夜夜爱夜夜做夜夜爽| 韩国久久久久久级做爰片| 国产欧美亚洲日韩图片| 国产男女猛烈无遮挡免费网站| 亚洲成色在线综合网站| 超碰国产天天做天天爽| 久久99av无色码人妻蜜| 成人无码av一区二区| 欧美成人午夜精品久久久| 国内精品久久久久伊人av| 无遮挡午夜男女xx00动态| 又粗又硬又黄又爽的视频永久| 日本熟妇中文字幕三级| 人妻熟女一区二区aⅴ林晓雪| 国产情侣草莓视频在线| 日本无码一区二区三区不卡免费| 小宝极品内射国产在线| 国语国产精精品国产国语清晰对话 | 天堂va欧美ⅴa亚洲va| 久久久久久久久蜜桃| 欧美日韩欧美| 国内精品久久久久影院薰衣草| 亚洲人成人无码www| 四虎影库久免费视频| 欧美人妻一区二区三区| 国产高清japanese在线播放e| 亚洲精品四区麻豆文化传媒| av免费网站在线观看| 97精品一区二区视频在线观看| 国产精品女上位好爽在线| 真人啪啪高潮喷水呻吟无遮挡| 极品少妇的粉嫩小泬视频|