在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNMT Antibody

  • 中文名稱:
    PNMT兔多克隆抗體
  • 貨號:
    CSB-PA562058
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, human liver cancer tissue, Jurkat cells, A549 cells, Primary antibody: CSB-PA562058(PNMT Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PNMT
  • 別名:
    Noradrenaline N-methyltransferase antibody; PENT antibody; Phenylethanolamine N-methyltransferase antibody; PNMT antibody; PNMT_HUMAN antibody; PNMTase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human PNMT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Converts noradrenaline to adrenaline.
  • 基因功能參考文獻:
    1. PNMT underexpression is associated with malignant pheochromocytoma and paraganglioma. PMID: 27007161
    2. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors. PMID: 24018397
    3. The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. PMID: 21866188
    4. PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population. PMID: 19952402
    5. In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality. PMID: 20090367
    6. PNMT variants in cis may interact with nuclear factors in trans to govern adrenergic activity. PMID: 20204374
    7. Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A. PMID: 11807261
    8. pharmacologic and biochemical evidence of beta-carboline 2N-methyltransferase activity PMID: 11900856
    9. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. PMID: 11958827
    10. homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment PMID: 12634439
    11. genetic variants of PNMT may play a role in the development of essential hypertension. PMID: 14553966
    12. Presence of local PNMT transcription in human heart after transplantation. PMID: 15848714
    13. disulfide-linked dimers are as active as the monomeric enzyme indicating that the crystal structure of the protein is a valid target for inhibitor design. PMID: 15893506
    14. Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element. PMID: 15968085
    15. Results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present. PMID: 16363801
    16. the differences in PNMT expression between normotensives and hypertensives are not determined by the polymorphisms in this gene, but rather by the interplay of gene expression regulators, which may vary among individuals PMID: 17645789
    17. We examined the correlation between reward dependence (RD) trait, and 5 polymorphisms in genes of norepinephrine pathways. We found that rs3764351 in PNMT was significantly associated with reward dependence trait. PMID: 18702937
    18. Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels. PMID: 18715275
    19. The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline. PMID: 19570037
    20. the reaction takes place via an SN2 mechanism with methyl transfer being rate-limiting PMID: 19733262
    21. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812

    顯示更多

    收起更多

  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
  • 數據庫鏈接:

    HGNC: 9160

    OMIM: 171190

    KEGG: hsa:5409

    STRING: 9606.ENSP00000269582

    UniGene: Hs.1892



主站蜘蛛池模板: 色综合久久蜜芽国产精品| 久久精品手机观看| av午夜福利一片免费看久久| 中文字幕乱码中文乱码777| 黑人玩弄人妻1区二区| 欧美国产精品久久久乱码| 男女爽爽无遮挡午夜视频| 日韩精品久久无码人妻中文字幕| 韩国精品一区二区三区无码视频| 香港特级三a毛片免费观看| 69国产精品久久久久久人妻| 日韩人妻无码精品久久久不卡| 中文www新版资源在线| av无码av无码专区| 美女18禁一区二区三区视频| 国产免费又爽又色又粗视频| 亚洲精品亚洲人成在线观看| 国产在线无码视频一区二区三区| 国产无套露脸在线观看| 国产男女爽爽爽免费视频| 97影院理论午夜伦不卡| 无码日日模日日碰夜夜爽| 扒开双腿疯狂进出爽爽爽视频| 国产免国产免费| 天堂va欧美va亚洲va好看va| 亚洲色素色无码专区| 在线观看特色大片免费网站| 亚洲最大成人综合网720p| 曰的好深好爽免费视频网站| 丰满熟妇人妻av无码区| 国产成人av大片大片在线播放 | 狠狠精品久久久无码中文字幕| 亚洲成av人片在线观看天堂无| 国语精品自产拍在线观看网站| 国产精品人成视频免费999| 四虎国产精品永久入口| av无码人妻波多野结衣| 玩超薄丝袜人妻的经历| 疯狂做受xxxx高潮不断| 少妇大叫太大太爽受不了在线观看| 肥臀熟女一区二区三区|