在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNMT Antibody, FITC conjugated

  • 中文名稱:
    PNMT兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA02939C0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNMT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNMT
  • 別名:
    Noradrenaline N-methyltransferase antibody; PENT antibody; Phenylethanolamine N-methyltransferase antibody; PNMT antibody; PNMT_HUMAN antibody; PNMTase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phenylethanolamine N-methyltransferase protein (1-176AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Converts noradrenaline to adrenaline.
  • 基因功能參考文獻:
    1. PNMT underexpression is associated with malignant pheochromocytoma and paraganglioma. PMID: 27007161
    2. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors. PMID: 24018397
    3. The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. PMID: 21866188
    4. PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population. PMID: 19952402
    5. In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality. PMID: 20090367
    6. PNMT variants in cis may interact with nuclear factors in trans to govern adrenergic activity. PMID: 20204374
    7. Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A. PMID: 11807261
    8. pharmacologic and biochemical evidence of beta-carboline 2N-methyltransferase activity PMID: 11900856
    9. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. PMID: 11958827
    10. homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment PMID: 12634439
    11. genetic variants of PNMT may play a role in the development of essential hypertension. PMID: 14553966
    12. Presence of local PNMT transcription in human heart after transplantation. PMID: 15848714
    13. disulfide-linked dimers are as active as the monomeric enzyme indicating that the crystal structure of the protein is a valid target for inhibitor design. PMID: 15893506
    14. Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element. PMID: 15968085
    15. Results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present. PMID: 16363801
    16. the differences in PNMT expression between normotensives and hypertensives are not determined by the polymorphisms in this gene, but rather by the interplay of gene expression regulators, which may vary among individuals PMID: 17645789
    17. We examined the correlation between reward dependence (RD) trait, and 5 polymorphisms in genes of norepinephrine pathways. We found that rs3764351 in PNMT was significantly associated with reward dependence trait. PMID: 18702937
    18. Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels. PMID: 18715275
    19. The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline. PMID: 19570037
    20. the reaction takes place via an SN2 mechanism with methyl transfer being rate-limiting PMID: 19733262
    21. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812

    顯示更多

    收起更多

  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
  • 數據庫鏈接:

    HGNC: 9160

    OMIM: 171190

    KEGG: hsa:5409

    STRING: 9606.ENSP00000269582

    UniGene: Hs.1892



主站蜘蛛池模板: 亚洲最大的成人网| 精品人妻少妇一区二区三区不卡 | 2021亚洲国产成a在线| 大又大又粗又硬又爽少妇毛片| 熟妇高潮喷沈阳45熟妇高潮喷| 中文字幕人妻中文av不卡专区| 久久人人爽人人爽人人片ⅴ | 2024av天堂手机在线观看| 亚洲午夜福利av一区二区无码| 欧美变态暴力牲交videos| 99国产精品久久久蜜芽| 中文天堂最新版在线www | 欧美亚洲日韩国产网站 | 日韩人妻不卡一区二区三区| 嫩草国产露脸精品国产软件| 精品人妻无码一区二区色欲产成人| 国产精品天干天干有线观看| 少妇愉情理伦片丰满丰满午夜| 蜜臀av综合网| 久久精品国自产拍| 国产狂喷潮在线观看| 国産精品久久久久久久| а√中文在线资源库| 青草精品国产福利在线视频| 丰满的少妇邻居中文bd| 麻花传媒mv国产免费观看视频| 丰满少妇69激情啪啪无| 亚洲中文字幕无码一区在线| 久久亚洲国产精品亚洲老地址| 免费无码av片流白浆在线观看| 激情综合色五月丁香六月欧美| 98国产精品综合一区二区三区| 2018天天躁夜夜躁狠狠躁| 人妻老妇乱子伦精品无码专区 | 日本另类αv欧美另类aⅴ| 日产精品一区二区| 无码人妻久久一区二区三区不卡| 欧美成人a天堂片在线观看| 国产肉丝袜在线观看| 妺妺窝人体色www聚色窝| 无码人妻丰满熟妇啪啪网站 |