在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNMT Antibody, HRP conjugated

  • 中文名稱:
    PNMT兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA02939B0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNMT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNMT
  • 別名:
    Noradrenaline N-methyltransferase antibody; PENT antibody; Phenylethanolamine N-methyltransferase antibody; PNMT antibody; PNMT_HUMAN antibody; PNMTase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phenylethanolamine N-methyltransferase protein (1-176AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Converts noradrenaline to adrenaline.
  • 基因功能參考文獻:
    1. PNMT underexpression is associated with malignant pheochromocytoma and paraganglioma. PMID: 27007161
    2. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors. PMID: 24018397
    3. The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. PMID: 21866188
    4. PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population. PMID: 19952402
    5. In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality. PMID: 20090367
    6. PNMT variants in cis may interact with nuclear factors in trans to govern adrenergic activity. PMID: 20204374
    7. Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A. PMID: 11807261
    8. pharmacologic and biochemical evidence of beta-carboline 2N-methyltransferase activity PMID: 11900856
    9. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. PMID: 11958827
    10. homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment PMID: 12634439
    11. genetic variants of PNMT may play a role in the development of essential hypertension. PMID: 14553966
    12. Presence of local PNMT transcription in human heart after transplantation. PMID: 15848714
    13. disulfide-linked dimers are as active as the monomeric enzyme indicating that the crystal structure of the protein is a valid target for inhibitor design. PMID: 15893506
    14. Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element. PMID: 15968085
    15. Results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present. PMID: 16363801
    16. the differences in PNMT expression between normotensives and hypertensives are not determined by the polymorphisms in this gene, but rather by the interplay of gene expression regulators, which may vary among individuals PMID: 17645789
    17. We examined the correlation between reward dependence (RD) trait, and 5 polymorphisms in genes of norepinephrine pathways. We found that rs3764351 in PNMT was significantly associated with reward dependence trait. PMID: 18702937
    18. Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels. PMID: 18715275
    19. The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline. PMID: 19570037
    20. the reaction takes place via an SN2 mechanism with methyl transfer being rate-limiting PMID: 19733262
    21. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812

    顯示更多

    收起更多

  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
  • 數據庫鏈接:

    HGNC: 9160

    OMIM: 171190

    KEGG: hsa:5409

    STRING: 9606.ENSP00000269582

    UniGene: Hs.1892



主站蜘蛛池模板: 国产精品无码a∨精品影院app| 美女露出奶头扒开尿口视频直播 | 欧美黑人巨大videos精品| 清纯唯美经典一区二区| 欧美国产日韩a在线视频| 久久人妻av中文字幕| 国产在线精品欧美日韩电影| 婷婷色中文字幕综合在线| 中国少妇内射xxxx狠干| av片日韩一区二区三区在线观看| 婷婷成人丁香五月综合激情| 国产成人无码一区二区在线观看| awww在线天堂bd资源在线| 一本久久a久久免费精品不卡| 又大又长粗又爽又黄少妇视频| 亚洲精品中文字幕| 亚洲日韩a∨无码久| 99热门精品一区二区三区无码 | 人妻互换一二三区激情视频| 亚洲.日韩.欧美另类| 日韩av片无码一区二区三区| 成人区人妻精品一区二区不卡视频| 天天夜碰日日摸日日澡性色av| 97色成人综合网站| 免费视频爱爱太爽了激情| 国产精品久久久久久久久动漫| 日韩电影一区二区三区| 最新亚洲一卡二卡三卡四卡| 欧洲亚洲国产成人综合色婷婷| 亚洲成在人线视av| 性一交一乱一乱一视频 | 中文字幕久久久久人妻中出| 久久久久88色偷偷| 国产精品无码翘臀在线观看| 国产精品亚洲色婷婷99久久精品| 国产精品第一区揄拍无码| 色综合天天天天综合狠狠爱| 成人看片黄a免费看在线| 国产成人精品123区免费视频| 国产熟女内射oooo| 久久综合伊人中文字幕|