在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIGN Antibody

  • 中文名稱:
    PIGN兔多克隆抗體
  • 貨號:
    CSB-PA017977LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA017977LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PIGN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PIGN
  • 別名:
    PIGN antibody; MCD4 antibody; GPI ethanolamine phosphate transferase 1 antibody; EC 2.-.-.- antibody; MCD4 homolog antibody; Phosphatidylinositol-glycan biosynthesis class N protein antibody; PIG-N antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human GPI ethanolamine phosphate transferase 1 protein (27-181AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PIGN Antibody (CSB-PA017977LA01HU),的標記方式是Non-conjugated。對于PIGN Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017977LB01HU PIGN Antibody, HRP conjugated ELISA
    FITC CSB-PA017977LC01HU PIGN Antibody, FITC conjugated
    Biotin CSB-PA017977LD01HU PIGN Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation.
  • 基因功能參考文獻:
    1. Loss of function PIGN alleles causes Fryns syndrome. Founder effect for PIGN intragenic deletion is observed in La Reunion and other Indian Ocean islands. PMID: 29330547
    2. PIGN is a novel biomarker of CIN and leukemic transformation/progression in a subgroup of patients with MDS or AML-MRC. PMID: 28187452
    3. Study reports compound heterozygous mutations in PIGN in two siblings with Fryns syndrome, and a homozygous mutation in an unrelated affected individual. However, two further individuals with Fryns syndrome did not carry mutations in this gene, suggesting genetic heterogeneity in this syndrome. PMID: 27038415
    4. Disease associated mutation L311W reduces enzymatic activity rather than affecting protein levels. PMID: 28327575
    5. PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells. PMID: 27980068
    6. PIGN mutation is associated with multiple congenital anomalies hypotonia seizures syndrome related epilepsy. PMID: 26394714
    7. The mutated PIGN caused a significant decrease of the overall glycosylphoshatidylinositol-anchored proteins and CD24 expression which is sufficient to cause severe phenotypic expression. PMID: 26364997
    8. Findings confirm that developmental delay, hypotonia, and epilepsy combined with congenital anomalies are common phenotypes of PIGN mutations and add progressive cerebellar atrophy to this clinical spectrum. PMID: 24253414
    9. PIGN encodes phosphatidylinositol-glycan biosynthesis class N protein. PMID: 22876578
    10. Multiple congenital anomalies-hypotonia-seizures syndrome is caused by a mutation in PIGN. PMID: 21493957

    顯示更多

    收起更多

  • 相關疾病:
    Multiple congenital anomalies-hypotonia-seizures syndrome 1 (MCAHS1)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    PIGG/PIGN/PIGO family, PIGN subfamily
  • 數據庫鏈接:

    HGNC: 8967

    OMIM: 606097

    KEGG: hsa:23556

    STRING: 9606.ENSP00000350263

    UniGene: Hs.157031



主站蜘蛛池模板: 成人精品视频一区二区三区| 人妻少妇乱子伦精品| 在线观看的网站| 亚洲小说图区综合在线| 国产精品自产拍在线18禁| 天天躁久久躁日日躁| av无码av在线a∨天堂毛片| 国产在线精品99一区不卡| 久久这里精品国产99丫e6| 中文字幕无线码一区2020青青| 亚洲va无码专区国产乱码| 97久久超碰国产精品最新| 国产色情又大又粗又黄的电影 | 国产成人愉拍精品| 久久精品aⅴ无码中文字字幕蜜桃| 欧美 丝袜 自拍 制服 另类| 国产精品丝袜肉丝出水| 国产欧美综合在线观看第十页| 亚洲国产成人久久一区| 无码午夜人妻一区二区三区不卡视频 | 久久99精品国产麻豆婷婷| 在线亚洲日产一区二区 | 久久这里只有精品首页| 国产婷婷色一区二区三区在线| av毛片无码中文字幕不卡| 久久久婷婷五月亚洲97色| 国产无遮挡又黄又爽免费视频| 国产成人无码综合亚洲日韩| 国产亚洲高清国产拍精品| 国产乱人伦偷精品视频下| a在线观看免费网站大全| 亚洲欧美精品午睡沙发| 亚洲中文字幕无码一区在线| 日产无码中文字幕av| 久久理论片午夜琪琪电影院| 精品人无码一区二区三区| 国产精品无码人妻一区二区在线| 亚洲无线观看国产精品| 一本一道久久综合久久| 国产免费又黄又爽又色毛| 国语精品一区二区三区|