在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIGN Antibody

  • 中文名稱:
    PIGN兔多克隆抗體
  • 貨號:
    CSB-PA017977LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA017977LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PIGN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PIGN
  • 別名:
    PIGN antibody; MCD4 antibody; GPI ethanolamine phosphate transferase 1 antibody; EC 2.-.-.- antibody; MCD4 homolog antibody; Phosphatidylinositol-glycan biosynthesis class N protein antibody; PIG-N antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human GPI ethanolamine phosphate transferase 1 protein (27-181AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PIGN Antibody (CSB-PA017977LA01HU),的標記方式是Non-conjugated。對于PIGN Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017977LB01HU PIGN Antibody, HRP conjugated ELISA
    FITC CSB-PA017977LC01HU PIGN Antibody, FITC conjugated
    Biotin CSB-PA017977LD01HU PIGN Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation.
  • 基因功能參考文獻:
    1. Loss of function PIGN alleles causes Fryns syndrome. Founder effect for PIGN intragenic deletion is observed in La Reunion and other Indian Ocean islands. PMID: 29330547
    2. PIGN is a novel biomarker of CIN and leukemic transformation/progression in a subgroup of patients with MDS or AML-MRC. PMID: 28187452
    3. Study reports compound heterozygous mutations in PIGN in two siblings with Fryns syndrome, and a homozygous mutation in an unrelated affected individual. However, two further individuals with Fryns syndrome did not carry mutations in this gene, suggesting genetic heterogeneity in this syndrome. PMID: 27038415
    4. Disease associated mutation L311W reduces enzymatic activity rather than affecting protein levels. PMID: 28327575
    5. PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells. PMID: 27980068
    6. PIGN mutation is associated with multiple congenital anomalies hypotonia seizures syndrome related epilepsy. PMID: 26394714
    7. The mutated PIGN caused a significant decrease of the overall glycosylphoshatidylinositol-anchored proteins and CD24 expression which is sufficient to cause severe phenotypic expression. PMID: 26364997
    8. Findings confirm that developmental delay, hypotonia, and epilepsy combined with congenital anomalies are common phenotypes of PIGN mutations and add progressive cerebellar atrophy to this clinical spectrum. PMID: 24253414
    9. PIGN encodes phosphatidylinositol-glycan biosynthesis class N protein. PMID: 22876578
    10. Multiple congenital anomalies-hypotonia-seizures syndrome is caused by a mutation in PIGN. PMID: 21493957

    顯示更多

    收起更多

  • 相關疾病:
    Multiple congenital anomalies-hypotonia-seizures syndrome 1 (MCAHS1)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    PIGG/PIGN/PIGO family, PIGN subfamily
  • 數據庫鏈接:

    HGNC: 8967

    OMIM: 606097

    KEGG: hsa:23556

    STRING: 9606.ENSP00000350263

    UniGene: Hs.157031



主站蜘蛛池模板: 亚洲色无码国产精品网站可下载| 亚洲色国产欧美日韩| 精品久久久久久久无码| 色吊丝av中文字幕| 3p人妻少妇对白精彩视频| 色偷偷人人澡久久超碰97| 99久久久无码国产精品免费砚床| 精品午夜福利在线观看| 伊人色综合久久天天小片| 成人片黄网站a毛片免费观看| 人妻少妇久久精品电影| 亚洲日韩av无码| 天堂√最新版中文在线地址| 国产三级在线观看免费| 又爽又黄又无遮挡的激情视频| 中文乱码免费一区二区三区| 99久久国产宗和精品1上映| 最新的国产成人精品2022| 久久综合国产乱子伦精品免费| 国产精品久久久久久久久久红粉| 人妻 日韩精品 中文字幕| 亚洲高清成人av电影网站| 国产av综合第一页| 影视先锋av资源噜噜| 国产精品不卡无码av在线播放| 色一情一乱一乱一区99av| 欧美两根一起进3p在线观看| 中文字幕丰满孑伦无码专区| 伊人情人色综合网站| 亚洲人成电影免费观看在线看| 无码潮喷a片无码高潮视频| 精品熟女日韩中文十区| 免费无码一区二区三区a片| 色情无码www视频无码区澳门| 大色综合色综合网站| 麻豆 美女 丝袜 人妻 中文| 女同免费毛片在线播放| 福利姬国产精品一区在线| av色综合久久天堂av色综合在| 久久精品亚洲男人的天堂| 99热在线精品国产观看|