在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIGN Antibody, FITC conjugated

  • 中文名稱:
    PIGN兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA017977LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PIGN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PIGN
  • 別名:
    PIGN antibody; MCD4 antibody; GPI ethanolamine phosphate transferase 1 antibody; EC 2.-.-.- antibody; MCD4 homolog antibody; Phosphatidylinositol-glycan biosynthesis class N protein antibody; PIG-N antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human GPI ethanolamine phosphate transferase 1 protein (27-181AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation.
  • 基因功能參考文獻(xiàn):
    1. Loss of function PIGN alleles causes Fryns syndrome. Founder effect for PIGN intragenic deletion is observed in La Reunion and other Indian Ocean islands. PMID: 29330547
    2. PIGN is a novel biomarker of CIN and leukemic transformation/progression in a subgroup of patients with MDS or AML-MRC. PMID: 28187452
    3. Study reports compound heterozygous mutations in PIGN in two siblings with Fryns syndrome, and a homozygous mutation in an unrelated affected individual. However, two further individuals with Fryns syndrome did not carry mutations in this gene, suggesting genetic heterogeneity in this syndrome. PMID: 27038415
    4. Disease associated mutation L311W reduces enzymatic activity rather than affecting protein levels. PMID: 28327575
    5. PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells. PMID: 27980068
    6. PIGN mutation is associated with multiple congenital anomalies hypotonia seizures syndrome related epilepsy. PMID: 26394714
    7. The mutated PIGN caused a significant decrease of the overall glycosylphoshatidylinositol-anchored proteins and CD24 expression which is sufficient to cause severe phenotypic expression. PMID: 26364997
    8. Findings confirm that developmental delay, hypotonia, and epilepsy combined with congenital anomalies are common phenotypes of PIGN mutations and add progressive cerebellar atrophy to this clinical spectrum. PMID: 24253414
    9. PIGN encodes phosphatidylinositol-glycan biosynthesis class N protein. PMID: 22876578
    10. Multiple congenital anomalies-hypotonia-seizures syndrome is caused by a mutation in PIGN. PMID: 21493957

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Multiple congenital anomalies-hypotonia-seizures syndrome 1 (MCAHS1)
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    PIGG/PIGN/PIGO family, PIGN subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8967

    OMIM: 606097

    KEGG: hsa:23556

    STRING: 9606.ENSP00000350263

    UniGene: Hs.157031



主站蜘蛛池模板: 高清一区二区三区日本久| 免费观看性欧美大片无片| 久久精品国产丝袜人妻| 人妻妺妺窝人体色www聚色窝| 又湿又黄裸乳漫画无遮挡网站 | 日韩精品亚洲色大成网站| 亚洲欧美日韩综合久久久久久| 亚洲成a∨人片在线观看不卡| 国产熟妇勾子乱视频| 亚洲人成无码网站18禁10| 国产又粗又硬又大爽黄老大爷| 成年女人永久免费观看视频| av无码一区二区大桥久未| 成年网站未满十八禁视频天堂 | 久久无码无码久久综合综合| 人妻系列影片无码专区| 1000部啪啪未满十八勿入| 伊人蕉久中文字幕无码专区| 精品久久国产综合婷婷五月| 人妻被按摩到潮喷中文不卡| 少妇与大狼拘作爱性a| 亚洲综合精品伊人久久| 国产精品美女久久久m| 国产免费牲交视频| 西西人体做爰大胆gogo| 久久国产精品萌白酱免费| 亚洲午夜av久久久精品影院色戒| 久久伊人蜜桃av一区二区| 日韩精品中文字幕无码专区| 狠狠做久久深爱婷婷| 韩国v欧美v亚洲v日本v| 天天爱天天做狠狠久久做| 无码任你躁久久久久久久| 人人人插人人费| 最新欧美精品一区二区三区| 亚洲国产成人一区二区精品区| 在线岛国片免费无码av| 成人av一本不卡二卡| 欧美人妻一区二区三区| 蜜臀av99无码精品国产专区| 东京热加勒比视频一区|