在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PIAS2 Antibody

PIAS2 Antibody

  • 中文名稱：
    PIAS2兔多克隆抗體
  • 貨號：
    CSB-PA017958GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Androgen receptor interacting protein 3 antibody; Androgen receptor-interacting protein 3 antibody; ARIP3 antibody; DAB2 interacting protein antibody; DAB2-interacting protein antibody; DIP antibody; E3 SUMO protein ligase PIAS2 antibody; E3 SUMO-protein ligase PIAS2 antibody; MIZ antibody; Miz1 antibody; Msx interacting zinc finger protein antibody; Msx-interacting zinc finger protein antibody; PIAS NY protein antibody; PIAS-NY protein antibody; PIAS2 antibody; PIAS2_HUMAN antibody; PIASX antibody; PIASX-ALPHA antibody; PIASX-BETA antibody; Protein inhibitor of activated STAT x antibody; Protein inhibitor of activated STAT, 2 antibody; Protein inhibitor of activated STAT2 antibody; SIZ2 antibody; Zinc finger, MIZ-type containing 4 antibody; ZMIZ4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PIAS2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
  • 基因功能參考文獻：
    1. results indicated that PIAS2-mediated SUMOylation constrained HCV replication PMID: 28973998
    2. These findings suggest that SUMO-1 modification of MDA5 possibly via PIAS2beta may play a role in the MDA5-mediated interferon response to viral infections. PMID: 21156324
    3. PIASx may function as a co-repressor of Stat4 PMID: 12716907
    4. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes PMID: 15580267
    5. the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1, identifying PIASxalpha as a novel corepressor of FLI-1 PMID: 16148010
    6. PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. PMID: 16713578

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle. Nucleus, PML body. Nucleus.
  • 蛋白家族：
    PIAS family
  • 組織特異性：
    Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
  • 數據庫鏈接：

    HGNC: 17311

    OMIM: 603567

    KEGG: hsa:9063

    STRING: 9606.ENSP00000465676

    UniGene: Hs.57769



主站蜘蛛池模板： 久在线观看福利视频| 国产剧情无码播放在线观看 | 国产精品视频一区二区三区不卡| 毛片免费视频在线观看| 欧美熟妇另类久久久久久不卡| 黑人巨茎大战欧美白妇| 中文字幕婷婷日韩欧美亚洲| 成年黄页网站大全免费无码| 久久国产色av免费观看| 蜜臀av在线播放一区二区三区| 久久aⅴ无码av高潮av喷吹| 国产亚洲精品无码不卡| 无码大潮喷水在线观看| 18禁裸体动漫美女无遮挡网站| 久久久精品人妻一区亚美研究所| 欧美18精品久久久无码午夜福利| 偷窥 亚洲 另类 图片 熟女| 强奷妇系列中文字幕| 国产精品人成视频免费999| 亚洲一区二区三区无码久久| 国产av久久久久精东av| 97在线观看永久免费视频| 播放男人添女人下边视频| 99re6热视频这里只精品首页| 天堂岛国av无码免费无禁网站| 久久久久久国产精品免费免费| 亚洲日本va午夜中文字幕一区| 国产va免费精品高清在线| 亚洲成av人片天堂网九九 | 极品国产主播粉嫩在线| 亚洲国产福利一区二区三区| 欧美疯狂性受xxxxx另类| 中文韩国午夜理伦三级好看| 久久国产免费福利永久| 少妇又色又紧又爽又刺激视频| 一卡二卡三卡视频| 国产av高清无亚洲| 成人无码无遮挡很h在线播放| 特级精品毛片免费观看| 秋霞国产成人精品午夜视频app| 亚洲精品av网站在线观看|