在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PIAS2 Antibody

PIAS2 Antibody

  • 中文名稱：
    PIAS2兔多克隆抗體
  • 貨號：
    CSB-PA003781
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COS7 cells using PIASx Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 Jurkat K562 cells using PIASx Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Androgen receptor interacting protein 3 antibody; Androgen receptor-interacting protein 3 antibody; ARIP3 antibody; DAB2 interacting protein antibody; DAB2-interacting protein antibody; DIP antibody; E3 SUMO protein ligase PIAS2 antibody; E3 SUMO-protein ligase PIAS2 antibody; MIZ antibody; Miz1 antibody; Msx interacting zinc finger protein antibody; Msx-interacting zinc finger protein antibody; PIAS NY protein antibody; PIAS-NY protein antibody; PIAS2 antibody; PIAS2_HUMAN antibody; PIASX antibody; PIASX-ALPHA antibody; PIASX-BETA antibody; Protein inhibitor of activated STAT x antibody; Protein inhibitor of activated STAT, 2 antibody; Protein inhibitor of activated STAT2 antibody; SIZ2 antibody; Zinc finger, MIZ-type containing 4 antibody; ZMIZ4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PIASx.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
  • 基因功能參考文獻：
    1. results indicated that PIAS2-mediated SUMOylation constrained HCV replication PMID: 28973998
    2. These findings suggest that SUMO-1 modification of MDA5 possibly via PIAS2beta may play a role in the MDA5-mediated interferon response to viral infections. PMID: 21156324
    3. PIASx may function as a co-repressor of Stat4 PMID: 12716907
    4. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes PMID: 15580267
    5. the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1, identifying PIASxalpha as a novel corepressor of FLI-1 PMID: 16148010
    6. PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. PMID: 16713578

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle. Nucleus, PML body. Nucleus.
  • 蛋白家族：
    PIAS family
  • 組織特異性：
    Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
  • 數據庫鏈接：

    HGNC: 17311

    OMIM: 603567

    KEGG: hsa:9063

    STRING: 9606.ENSP00000465676

    UniGene: Hs.57769



主站蜘蛛池模板： 国产亚洲精品福利在线无卡一| 鲁鲁狠狠狠7777一区二区| 在线观看特色大片免费视频 | 亚洲sm另类一区二区三区| 精品无码久久久久国产app| 国产卡一卡二卡三| 色综合视频一区二区三区| 成人免费无遮挡在线播放| 体验区试看120秒啪啪免费| 色一情一乱一乱一区99av白浆| 欧美亚洲综合在线一区| 在线观看无码不卡av| 亚洲精品一区二区玖玖爱| 国产va免费精品观看| 久久久橹橹橹久久久久| 国产suv精品一区二区62| 天堂网www中文在线| 亚洲大尺度无码无码专线| 久久国国产免费999| 国产成人无码aa精品一区| 色五月五月丁香亚洲综合网| 青青草国产久久精品| 日本japanese漂亮丰满| 国产乱子伦精品无码专区| 欧美日韩国产一区二区三区不卡| av天堂久久精品影音先锋| 欧美性大战久久久久xxx| 宅宅少妇无码| 在线看片无码永久av| 奇米777四色成人影视| 亚洲国产区男人本色| 暖暖视频日本在线观看| 日韩乱码在线观看免费视频网站| 中文字幕人妻丝袜成熟乱 | 男男又爽又黄又无遮挡网站| 国产精品十八禁在线观看| 与子敌伦刺激对白播放的优点| 狠狠色噜噜狠狠狠狠蜜桃| 色欲网天天无码av| 久久久久亚洲精品无码网址| 成人啪啪高潮不断观看|