在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PIAS2 Antibody

PIAS2 Antibody

  • 中文名稱：
    PIAS2兔多克隆抗體
  • 貨號：
    CSB-PA13299A0Rb
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PIAS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Androgen receptor interacting protein 3 antibody; Androgen receptor-interacting protein 3 antibody; ARIP3 antibody; DAB2 interacting protein antibody; DAB2-interacting protein antibody; DIP antibody; E3 SUMO protein ligase PIAS2 antibody; E3 SUMO-protein ligase PIAS2 antibody; MIZ antibody; Miz1 antibody; Msx interacting zinc finger protein antibody; Msx-interacting zinc finger protein antibody; PIAS NY protein antibody; PIAS-NY protein antibody; PIAS2 antibody; PIAS2_HUMAN antibody; PIASX antibody; PIASX-ALPHA antibody; PIASX-BETA antibody; Protein inhibitor of activated STAT x antibody; Protein inhibitor of activated STAT, 2 antibody; Protein inhibitor of activated STAT2 antibody; SIZ2 antibody; Zinc finger, MIZ-type containing 4 antibody; ZMIZ4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 SUMO-protein ligase PIAS2 protein (1-572AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PIAS2 Antibody (CSB-PA13299A0Rb)，的標記方式是Non-conjugated。對于PIAS2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA13299B0Rb PIAS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA13299C0Rb PIAS2 Antibody, FITC conjugated
    Biotin CSB-PA13299D0Rb PIAS2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
  • 基因功能參考文獻：
    1. results indicated that PIAS2-mediated SUMOylation constrained HCV replication PMID: 28973998
    2. These findings suggest that SUMO-1 modification of MDA5 possibly via PIAS2beta may play a role in the MDA5-mediated interferon response to viral infections. PMID: 21156324
    3. PIASx may function as a co-repressor of Stat4 PMID: 12716907
    4. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes PMID: 15580267
    5. the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1, identifying PIASxalpha as a novel corepressor of FLI-1 PMID: 16148010
    6. PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. PMID: 16713578

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle. Nucleus, PML body. Nucleus.
  • 蛋白家族：
    PIAS family
  • 組織特異性：
    Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
  • 數據庫鏈接：

    HGNC: 17311

    OMIM: 603567

    KEGG: hsa:9063

    STRING: 9606.ENSP00000465676

    UniGene: Hs.57769



主站蜘蛛池模板： 99精品视频在线观看免费蜜桃| 女人裸露免费视频无遮挡网站 | 欧美牲交a欧美牲交aⅴ| 女女互磨互喷水高潮les呻吟 | 在线观看无码不卡av| 男人扒开女人双腿猛进视频| 97人妻免费碰视频碰免| 久久99精品久久久久蜜芽| 国产露脸无套对白在线播放| 国产动作大片中文字幕| 成人一区二区免费中文字幕视频 | 97久久婷婷五月综合色d啪蜜芽| 亚洲人成77777在线播放网站不卡| 亚洲人成网站在线观看69影院| 免费夜色污私人影院在线观看| 中国性欧美videofree精品| 国产产品亚洲产品| 国产精品a无线| 很色很爽很黄裸乳视频| 亚洲国产成人精品无码区花野真一| 久久久一本精品99久久精品88| 国外av无码精品国产精品| 国内精品九九久久久精品| 99爱在线精品视频免费观看 | 可以直接看的无码av| 亚洲高清国产拍精品网络战| 亚洲国产精品无码久久一区二区| 国产乱人伦精品一区二区在线观看| 尤物av无码色av无码| 中文无码精品a∨在线观看| 又硬又粗进去好爽免费| 亚洲人成色777777老人头| 丰满岳乱妇一区二区三区| 中文字幕无码专区人妻系列| 欧美午夜成人片在线观看| 精品一区二区三区免费播放| 精品久久久久久久久午夜福利| 无码大潮喷水在线观看| 精品久久久久久人妻无码中文字幕| 一二三四视频社区在线| 中文字幕久久精品一区二区三区|