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  4. PHLDA3 Antibody

PHLDA3 Antibody

  • 中文名稱：
    PHLDA3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003757
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using PHLDA3 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PHLDA3
  • 別名：
    PHLA3_HUMAN antibody; PHLDA 3 antibody; phlda3 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology like domain family A member 3 antibody; Pleckstrin homology-like domain family A member 3 antibody; TDAG51/Ipl homolog 1 antibody; TDAG51/Ipl homologue 1 antibody; TIH 1 antibody; TIH1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PHLDA3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. although iPSCs and ESCs share lots of common features, we did not find that PHLDA3 is important to ES cell differentiation. PMID: 28588267
    2. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs PMID: 25667479
    3. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs). PMID: 24912192
    4. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression PMID: 21753719
    5. Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation. PMID: 19203586

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  • 亞細(xì)胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    PHLDA3 family
  • 組織特異性：
    Widely expressed with lowest expression in liver and spleen.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8934

    OMIM: 607054

    KEGG: hsa:23612

    STRING: 9606.ENSP00000356278

    UniGene: Hs.153944



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