在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PHLDA3 Antibody

PHLDA3 Antibody

  • 中文名稱：
    PHLDA3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003757
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using PHLDA3 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PHLDA3
  • 別名：
    PHLA3_HUMAN antibody; PHLDA 3 antibody; phlda3 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology like domain family A member 3 antibody; Pleckstrin homology-like domain family A member 3 antibody; TDAG51/Ipl homolog 1 antibody; TDAG51/Ipl homologue 1 antibody; TIH 1 antibody; TIH1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PHLDA3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. although iPSCs and ESCs share lots of common features, we did not find that PHLDA3 is important to ES cell differentiation. PMID: 28588267
    2. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs PMID: 25667479
    3. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs). PMID: 24912192
    4. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression PMID: 21753719
    5. Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation. PMID: 19203586

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    PHLDA3 family
  • 組織特異性：
    Widely expressed with lowest expression in liver and spleen.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8934

    OMIM: 607054

    KEGG: hsa:23612

    STRING: 9606.ENSP00000356278

    UniGene: Hs.153944



主站蜘蛛池模板： 国产成人a区在线观看| 成年女性特黄午夜视频免费看 | 亚洲线精品一区二区三区影音先锋 | 中文字幕人成乱码熟女香港 | 精品熟人妻一区二区三区四区不卡| 2020精品自拍视频曝光| 在线看片免费人成视频国产片| 国产成人无码一区二区在线播放| 日本高清在线一区二区三区 | 久久精品伊人久久精品伊人| 乱人伦中文字幕成人网站在线| 久久99精品国产99久久6尤物 | 狠狠躁夜夜躁人人躁婷婷视频| 国产成a人片在线观看视频下载| 色欲久久人妻内射| 性按摩无码中文| 亚洲 小说 欧美 激情 另类| 白嫩日本少妇做爰| 在线v片免费观看视频| 99精品国产福久久久久久| 人妻无码久久精品| 亚洲欧洲日本无在线码| 骚虎成人免费99xx| 少妇av射精精品蜜桃专区| 妺妺窝人体色www在线小说| 日本免费一区二区三区日本| 亚洲精品久久久久一区二区三区| 无码av大香线蕉伊人久久| 精品视频一区二区三三区四区| 亚洲国产成人无码av在线播放| 国产精品丰臀| 国产日产欧洲无码视频| 侵犯强奷高清无码| 天天躁人人躁人人躁狂躁| 999zyz玖玖资源站永久| 成人国产片视频在线观看| 久久www免费人成看片入口| 国产精品无码一区二区三区电影 | 久久无码人妻丰满熟妇区毛片| 纯肉无遮挡无码日本动漫| 18禁成人黄网站免费观看久久|