在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PHLDA3 Antibody, FITC conjugated

  • 中文名稱:
    PHLDA3兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA017932LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PHLDA3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PHLDA3
  • 別名:
    PHLA3_HUMAN antibody; PHLDA 3 antibody; phlda3 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology like domain family A member 3 antibody; Pleckstrin homology-like domain family A member 3 antibody; TDAG51/Ipl homolog 1 antibody; TDAG51/Ipl homologue 1 antibody; TIH 1 antibody; TIH1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn):
    1. although iPSCs and ESCs share lots of common features, we did not find that PHLDA3 is important to ES cell differentiation. PMID: 28588267
    2. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs PMID: 25667479
    3. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs). PMID: 24912192
    4. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression PMID: 21753719
    5. Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation. PMID: 19203586

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    PHLDA3 family
  • 組織特異性:
    Widely expressed with lowest expression in liver and spleen.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8934

    OMIM: 607054

    KEGG: hsa:23612

    STRING: 9606.ENSP00000356278

    UniGene: Hs.153944



主站蜘蛛池模板: 特级a欧美做爰片三人交| 亚洲国产精品成人久久蜜臀 | 超碰国产精品人人做人人爱| 亚洲永久网址在线观看| 免费人成视频网站在线下载| 久久超碰极品视觉盛宴| 精品无码专区毛片| 国产亚洲精品久久久久久大师| 欧美两根一起进3p做受视频| 国产精品成人免费一区久久羞羞| 国产精品毛片一区二区| 亚洲乱亚洲乱妇无码| 人妻一区二区三区高清av专区| 国产成人无码a区在线观看视频免费| 久久综合伊人| 亚洲精品国产电影| 日本免码va在线看免费| 欧美国产亚洲日韩在线二区| 性一交一乱一乱一视频| 无码一区二区三区| 伊人久久久av老熟妇色| 国产在线观看免费人成视频| 亚洲色大成网站www永久| 少妇愉情理伦片丰满丰满午夜| 在线观看国产日韩亚洲中| 2022国产日产欧产精品| 337p日本欧洲亚洲大胆| 国产午夜亚洲精品区| 精品国产福利在线视频| 一卡二卡3卡四卡网站精品| 欧洲吸奶大片在线看| 欧美精品中文字幕亚洲专区| 四虎亚洲精品高清在线观看| 亚洲高清国产拍精品闺蜜合租| 久久天天躁夜夜躁狠狠85麻豆 | 成人无码男男gv在线观看网站| 久久影院午夜伦手机不四虎卡| 久久天天躁狠狠躁夜夜2020一 | 一二三四区无产乱码1000集| 亚洲午夜福利av一区二区无码| 又黄又硬又湿又刺激视频免费|