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PEX14 Antibody

  • 中文名稱:
    PEX14兔多克隆抗體
  • 貨號:
    CSB-PA775947
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from A549 cells, using PEX14 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PEX14 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEX14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEX14
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human PEX14.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.
  • 基因功能參考文獻:
    1. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes. PMID: 27311714
    2. PEX14 is the 13th PEX gene responsible for peroxisome biogenesis disorders. Thus far, only two patients with PEX14 deficiency have been reported. PMID: 26627464
    3. The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. PMID: 24235149
    4. interaction of PEX5 with catalase and PEX14 PMID: 21976670
    5. PEX14 is a multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules. PMID: 21525035
    6. Serves as a transcriptional corepressor in addition to its peroxisomal function. PMID: 11863372
    7. peroxisomal localization of Pex14p is affected by Pex13p PMID: 14715663
    8. a new complementation group of the peroxisome biogenesis disorders with PEX14 as the defective gene PMID: 15146459
    9. This report represents the second PEX14-deficiency associated with Zellweger syndrome and the first documentation of a PEX14-deficient patient with detailed clinical follow-up and biochemical, morphological, and radiological data. PMID: 18285423
    10. N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 and Pex19 ligand helices bind competitively to the same surface in Pex14(N) albeit with opposite directionality. PMID: 19197237
    11. analysis of the human Pex5.Pex14.PTS1 protein complex structure obtained by small angle X-ray scattering PMID: 19584060

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  • 相關疾病:
    Peroxisome biogenesis disorder complementation group K (PBD-CGK); Peroxisome biogenesis disorder 13A (PBD13A)
  • 亞細胞定位:
    Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Peroxin-14 family
  • 數據庫鏈接:

    HGNC: 8856

    OMIM: 601791

    KEGG: hsa:5195

    STRING: 9606.ENSP00000349016

    UniGene: Hs.149983



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