在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDS5B Antibody

  • 中文名稱:
    PDS5B兔多克隆抗體
  • 貨號:
    CSB-PA243039
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA243039(PDS5B Antibody) at dilution 1/316.6, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PDS5B
  • 別名:
    PDS5B antibody; APRIN antibody; AS3 antibody; KIAA0979 antibody; Sister chromatid cohesion protein PDS5 homolog B antibody; Androgen-induced proliferation inhibitor antibody; Androgen-induced prostate proliferative shutoff-associated protein AS3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human PDS5B
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
  • 基因功能參考文獻:
    1. Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions. PMID: 27549742
    2. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    3. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
    4. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
    5. Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes. PMID: 26971492
    6. APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish. PMID: 27924011
    7. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    8. Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein. PMID: 22293751
    9. Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma. PMID: 20383194
    10. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein) PMID: 12072405
    11. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. PMID: 18499069
    12. identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon PMID: 19412548
    13. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. PMID: 19737411

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    PDS5 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 20418

    OMIM: 605333

    KEGG: hsa:23047

    STRING: 9606.ENSP00000313851

    UniGene: Hs.744901



主站蜘蛛池模板: 中文字幕aⅴ人妻一区二区| 无码播放一区二区三区| 日本饥渴人妻欲求不满| 精品熟人妻一区二区三区四区不卡| 久久无码潮喷a片无码高潮| 日99久9在线 | 免费| 奶头又大又白喷奶水av| 999zyz玖玖资源站永久| 久久精品国产精品久久久| 亚洲成aⅴ人最新无码| 免费观看成人毛片a片| 午夜成人亚洲理伦片在线观看| 日日拍夜夜嗷嗷叫|日日摸| 国内免费视频成人精品| 一本一道久久a久久精品综合| 色拍拍在线精品视频| 老司机久久99久久精品播放免费| 精品高朝久久久久9999| 国产一卡二卡三新区2022| 日韩精品一区二区三区视频| 欧美日韩国产免费一区二区三区| 国产传媒麻豆剧精品av国产| 潮喷大喷水系列无码| 成人区人妻精品一熟女| 国产成人精品成人a在线观看| 色六月婷婷亚洲婷婷六月| 欧美成人国产精品高潮| 亚洲成av人片在线观看无码不卡| 成 人 色综合 综合网站| 欧美 亚洲 日韩 中文2019| 女女互磨互喷水高潮les呻吟| 久在线精品视频线观看| 日韩国产精品人妻无码久久久| 狠狠色狠狠色综合网| 国产三级久久久精品麻豆三级 | 国产精品久久国产三级国| 欧美成人精精品一区二区| 欧美日韩精品一区二区性色a+v| 内射囯产旡码丰满少妇| 四虎影视在线影院在线观看| 久久99av无色码人妻蜜|