在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDS5B Antibody, HRP conjugated

PDS5B Antibody, HRP conjugated

  • 中文名稱：
    PDS5B兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA889108LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDS5B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDS5B
  • 別名：
    PDS5B antibody; APRIN antibody; AS3 antibody; KIAA0979 antibody; Sister chromatid cohesion protein PDS5 homolog B antibody; Androgen-induced proliferation inhibitor antibody; Androgen-induced prostate proliferative shutoff-associated protein AS3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sister chromatid cohesion protein PDS5 homolog B protein (3-124AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
  • 基因功能參考文獻(xiàn)：
    1. Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions. PMID: 27549742
    2. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    3. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
    4. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
    5. Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes. PMID: 26971492
    6. APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish. PMID: 27924011
    7. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    8. Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein. PMID: 22293751
    9. Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma. PMID: 20383194
    10. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein) PMID: 12072405
    11. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. PMID: 18499069
    12. identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon PMID: 19412548
    13. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. PMID: 19737411

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    PDS5 family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20418

    OMIM: 605333

    KEGG: hsa:23047

    STRING: 9606.ENSP00000313851

    UniGene: Hs.744901



主站蜘蛛池模板： 6080yyy午夜理论片中无码| 国产一区二区丝袜高跟鞋| 性动态图av无码专区| 香蕉久久福利院| 国语做受对白xxxxx在线| 中字幕久久久人妻熟女天美传媒| 中国精学生妹品射精久久| 亚洲国产成人久久综合一区| 99久久99久久久精品齐齐综合色圆| 日韩亚洲国产综合高清| 伊人久久大香线蕉无码| 99精品人妻无码专区在线视频区| 国产精品无码av片在线观看播| 国产成+人+综合+亚洲欧美| 国产又粗又猛又爽又黄| 亚洲精品国产精品乱码视色| 久久中文字幕乱码久久午夜| 免费无码av片流白浆在线观看| 影视先锋av资源噜噜| 成人区精品一区二区婷婷| 无码国模大尺度视频在线观看| 国产免费一区二区三区在线观看| 亚洲国产无线乱码在线观看| 99久久精品国产成人综合| 中国少妇偷人hd| 欧美人与动牲交a精品| 99国产精品久久久蜜芽| 国产成人精品视频国产| 国精产品一区一区三区| 精品无码中文视频在线观看| 国产精品内射视频免费| 亚洲性无码av在线dvd| 夜夜夜夜曰天天天天拍国产| 国产在线精品无码二区| 蜜桃麻豆www久久国产sex| 精品综合久久久久久888蜜芽| 亚洲精品无码av专区最新| 乱色国内精品视频在线| 人人妻人人澡人人爽欧美一区双| 人人超碰人摸人爱| 综合色区国产亚洲另类|