在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDS5B Antibody, Biotin conjugated

  • 中文名稱:
    PDS5B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA889108LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDS5B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDS5B
  • 別名:
    PDS5B antibody; APRIN antibody; AS3 antibody; KIAA0979 antibody; Sister chromatid cohesion protein PDS5 homolog B antibody; Androgen-induced proliferation inhibitor antibody; Androgen-induced prostate proliferative shutoff-associated protein AS3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sister chromatid cohesion protein PDS5 homolog B protein (3-124AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
  • 基因功能參考文獻:
    1. Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions. PMID: 27549742
    2. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    3. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
    4. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
    5. Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes. PMID: 26971492
    6. APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish. PMID: 27924011
    7. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    8. Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein. PMID: 22293751
    9. Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma. PMID: 20383194
    10. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein) PMID: 12072405
    11. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. PMID: 18499069
    12. identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon PMID: 19412548
    13. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. PMID: 19737411

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    PDS5 family
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20418

    OMIM: 605333

    KEGG: hsa:23047

    STRING: 9606.ENSP00000313851

    UniGene: Hs.744901



主站蜘蛛池模板: 亚洲精品国产一区二区精华液| 天堂а√中文在线| 国产亚洲精品视觉盛宴| 亚洲精品一区二区三区中文字幕 | 欧美深度肠交惨叫| 少妇被粗大的猛进69视频| 超级碰97直线国产免费公开| 精品三级久久久久电影网| 亚洲人成网站在线观看69影院 | 国产av精品毛片一区二区三区| 狠狠躁夜夜躁人人爽天天bl| 婷婷成人小说综合专区| 亚洲aⅴ男人的天堂在线观看| 一性一交一口添一摸视频 | 午夜福利不卡片在线机免费视频 | 国产好爽…又高潮了毛片| 中日韩精品无码一区二区三区| 亚洲六月丁香六月婷婷| 小妖精又紧又湿高潮h视频69| 国产精品一区二区av| 久久久久99精品成人品| 日韩精品亚洲人成在线观看| 么公的好大好硬好深好爽视频 | 国产成人精品综合在线观看 | 1000部夫妻午夜免费| 亚洲精品动漫免费二区| 亚洲午夜无码久久yy6080| 丰满人妻熟妇乱又仑精品| 天干天干天啪啪夜爽爽av| 亚洲精品人成网线在线播放va | 国产国拍精品av在线观看按摩 | 国产精品亚洲专区无码牛牛| 亚洲伊人成综合人影院青青青| 亚洲人成网站18禁止中文字幕| 荫道bbwbbb高潮潮喷 | 国产美女精品中文网蜜芽宝贝| 久久精品国产精品亚洲艾草网 | 日韩~欧美一中文字幕| 麻豆高清免费国产一区| 日产无码中文字幕av| 国产多人群p刺激交换视频|