在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDS5B Antibody, Biotin conjugated

  • 中文名稱:
    PDS5B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA889108LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PDS5B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDS5B
  • 別名:
    PDS5B antibody; APRIN antibody; AS3 antibody; KIAA0979 antibody; Sister chromatid cohesion protein PDS5 homolog B antibody; Androgen-induced proliferation inhibitor antibody; Androgen-induced prostate proliferative shutoff-associated protein AS3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sister chromatid cohesion protein PDS5 homolog B protein (3-124AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
  • 基因功能參考文獻:
    1. Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions. PMID: 27549742
    2. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    3. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
    4. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
    5. Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes. PMID: 26971492
    6. APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish. PMID: 27924011
    7. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    8. Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein. PMID: 22293751
    9. Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma. PMID: 20383194
    10. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein) PMID: 12072405
    11. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. PMID: 18499069
    12. identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon PMID: 19412548
    13. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. PMID: 19737411

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    PDS5 family
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20418

    OMIM: 605333

    KEGG: hsa:23047

    STRING: 9606.ENSP00000313851

    UniGene: Hs.744901



主站蜘蛛池模板: 国产精品vⅰdeoxxxx国产| 无遮挡十八禁污污网站免费| 亚洲乱码中文字幕久久孕妇黑人 | 亚洲s码欧洲m码国产av| 动漫av一区二区在线观看| 国产suv精二区| 人妻熟妇乱又伦精品视频无广告| 国产精品厕所| 免费观看黄网站在线播放| 少妇被粗大猛进进出出s小说| 鲁一鲁一鲁一鲁一澡| 国产av一区二区三区无码野战| 午夜免费无码福利视频| 在线观看成人无码中文av天堂不卡| 人人摸人人搞人人透| 国产精品久久久久久久久电影网| 少妇挑战三个黑人惨叫4p国语 | 成人毛片无码一区二区三区| 双腿张开被9个黑人调教影片 | 精品久久久久久久无码| 伊人久久大香线蕉综合网站| 日韩精品区一区二区三vr| 国产一区丝袜在线播放| 内谢少妇xxxxx8老少交| 免费国产午夜视频在线| 午夜视频在线瓜伦| 在线观看无码不卡av| 丝袜高跟麻麻浓精受孕人妻| 果冻传媒一区二区天美传媒| 免费无码专区在线视频| 久久精品国产成人av| 欧美交换配乱吟粗大25p | 老太脱裤子让老头玩xxxxx| 老司机导航亚洲精品导航| 欧美裸体xxxx极品| 欧美男男大粗吊1069| 99久久99久久精品国产片| 国产午夜鲁丝无码拍拍| 女人与牲口性恔配视频免费| 午夜无码人妻av大片色欲| 日本午夜免费福利视频|