在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCNT Antibody, Biotin conjugated

  • 中文名稱:
    PCNT兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017627LD11HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PCNT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Centrosome Marker antibody; Ken antibody; Kendrin antibody; KIAA0402 antibody; MOPD2 antibody; PCN antibody; PCNT 2 antibody; PCNT antibody; PCNT B antibody; PCNT_HUMAN antibody; PCNT1 antibody; PCNT2 antibody; PCNTB antibody; PCTN2 antibody; Pericentrin 1 antibody; Pericentrin 2 antibody; Pericentrin 380 antibody; Pericentrin antibody; Pericentrin B antibody; Pericentrin-B antibody; SCKL4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pericentrin protein (250-600AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
  • 基因功能參考文獻:
    1. High pericentrin expression is associated with Disruptive Cilia Formation in down syndrome. PMID: 30100262
    2. we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms PMID: 26231886
    3. PCNT has to be phosphorylated by PLK1 to be a suitable substrate of separase. PMID: 26647647
    4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
    5. The CEP215-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis. PMID: 24466316
    6. Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome. PMID: 23979692
    7. PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II. PMID: 24106199
    8. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
    9. The pericentrin B cleavage is essential for timely centriole disengagement and duplication. PMID: 22722493
    10. Kendrin is a novel and crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. PMID: 22542101
    11. Expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects, was analyzed. PMID: 22552340
    12. The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis. PMID: 22184200
    13. PCNT has a crucial role in tooth development; teeth of a patient with a novel homozygous mutation p.Glu1154X are probably the smallest ever reported. PMID: 21567919
    14. Severe insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital. PMID: 21270239
    15. Microcephalic osteodysplastic primordial dwarfism type II is a genetically homogeneous condition due to loss-of-function of pericentrin. PMID: 19643772
    16. Results found no significant association between the pericentrin gene and schizophrenia in the Japanese population. This gene may not play a major role independently in the etiology of SZ. PMID: 19937158
    17. The NESs and NLS of pericentrin are essential for its subcellular localization and nucleocytoplasmic trafficking during the cell cycle.(Pericentrin) PMID: 20567258
    18. Data suggest that pericentrin may regulate the intracellular distribution and secretion of insulin. PMID: 20676397
    19. CG-NAP and kendrin provide sites for microtubule nucleation in the mammalian centrosome by anchoring gamma-TuRC PMID: 12221128
    20. results confirm that MT1-MMP cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP functionality PMID: 16251193
    21. Elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder. PMID: 17884020
    22. Mutations in PCNT cause Seckel syndrome with defective ATR-dependent DNA damage signaling. PMID: 18157127
    23. study found that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) in 25 patients PMID: 18174396
    24. Upregulation of pericentrin is associated with increased angiogenesis and prostate tumor cell proliferation PMID: 18701509
    25. These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics. PMID: 18955030
    26. The association of PCNT2 and DBZ with schizophrenia and bipolar disorder in a case-control study of Japanese cohorts, was examined. PMID: 19191256
    27. results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of major depressive disorder in the Japanese population PMID: 19448849
    28. Results show that a lack of microcephalin or pericentrin results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B-Cdk1. PMID: 19546241

    顯示更多

    收起更多

  • 相關疾病:
    Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
  • 組織特異性:
    Expressed in all tissues tested, including placenta, liver, kidney and thymus.
  • 數據庫鏈接:

    HGNC: 16068

    OMIM: 210720

    KEGG: hsa:5116

    STRING: 9606.ENSP00000352572

    UniGene: Hs.474069



主站蜘蛛池模板: 青青草原亚洲| 欧美牲交a欧美牲交vdo18| 亚洲性色av性色在线观看| 三级网站视频在在线播放| 久久久久国产精品嫩草影院 | 综合无码成人aⅴ视频在线观看| 人摸人人人澡人人超碰97| 三上悠亚久久精品| 国产福利视频| 国产高清无套内谢| 日产精品99久久久久久| 国产精品亚洲色婷婷99久久精品 | 天堂网www在线资源网| 成年免费视频黄网站zxgk| 青草视频在线观看视频| 日本天天日噜噜噜| 国产办公室秘书无码精品99| 久久久久九九精品影院| 国产av夜夜欢一区二区三区| 一本一道色欲综合网| 玩弄丰满少妇xxxxx性多毛| 日本夜爽爽一区二区三区| 又粗又硬整进去好爽视频| 国产亚洲精品福利视频| 内射爽无广熟女亚洲| 性人久久网av| 高潮毛片无遮挡高清免费视频| 国产最大成人亚洲精品| 成人精品视频一区二区| 亚洲精品乱码久久久久久蜜桃不卡| 77se77亚洲欧美在线| 国产成人综合色就色综合| 欧美成人aaa片一区国产精品| 女人和拘做受全程看视频| 亚洲 欧洲 日韩 综合av| 大地资源网第二页免费观看| 换脸国产av一区二区三区| 人人莫人人擦人人看| 成人aaa片一区国产精品| 亚洲欧美中文日韩在线视频一| 亚洲天堂在线观看完整版|