在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Pericentrin (PCNT), partial

Recombinant Human Pericentrin (PCNT), partial

  • 中文名稱：
    人PCNT重組蛋白
  • 貨號：
    CSB-YP017627HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PCNT重組蛋白
  • 貨號：
    CSB-EP017627HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PCNT重組蛋白
  • 貨號：
    CSB-EP017627HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PCNT重組蛋白
  • 貨號：
    CSB-BP017627HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PCNT重組蛋白
  • 貨號：
    CSB-MP017627HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Centrosome Marker; Ken; Kendrin; KIAA0402; MOPD2; PCN; PCNT 2; PCNT; PCNT B; PCNT_HUMAN; PCNT1; PCNT2; PCNTB; PCTN2; Pericentrin 1; Pericentrin 2; Pericentrin 380; Pericentrin; Pericentrin B; Pericentrin-B; SCKL4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
  • 基因功能參考文獻：
    1. High pericentrin expression is associated with Disruptive Cilia Formation in down syndrome. PMID: 30100262
    2. we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms PMID: 26231886
    3. PCNT has to be phosphorylated by PLK1 to be a suitable substrate of separase. PMID: 26647647
    4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
    5. The CEP215-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis. PMID: 24466316
    6. Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome. PMID: 23979692
    7. PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II. PMID: 24106199
    8. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
    9. The pericentrin B cleavage is essential for timely centriole disengagement and duplication. PMID: 22722493
    10. Kendrin is a novel and crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. PMID: 22542101
    11. Expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects, was analyzed. PMID: 22552340
    12. The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis. PMID: 22184200
    13. PCNT has a crucial role in tooth development; teeth of a patient with a novel homozygous mutation p.Glu1154X are probably the smallest ever reported. PMID: 21567919
    14. Severe insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital. PMID: 21270239
    15. Microcephalic osteodysplastic primordial dwarfism type II is a genetically homogeneous condition due to loss-of-function of pericentrin. PMID: 19643772
    16. Results found no significant association between the pericentrin gene and schizophrenia in the Japanese population. This gene may not play a major role independently in the etiology of SZ. PMID: 19937158
    17. The NESs and NLS of pericentrin are essential for its subcellular localization and nucleocytoplasmic trafficking during the cell cycle.(Pericentrin) PMID: 20567258
    18. Data suggest that pericentrin may regulate the intracellular distribution and secretion of insulin. PMID: 20676397
    19. CG-NAP and kendrin provide sites for microtubule nucleation in the mammalian centrosome by anchoring gamma-TuRC PMID: 12221128
    20. results confirm that MT1-MMP cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP functionality PMID: 16251193
    21. Elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder. PMID: 17884020
    22. Mutations in PCNT cause Seckel syndrome with defective ATR-dependent DNA damage signaling. PMID: 18157127
    23. study found that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) in 25 patients PMID: 18174396
    24. Upregulation of pericentrin is associated with increased angiogenesis and prostate tumor cell proliferation PMID: 18701509
    25. These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics. PMID: 18955030
    26. The association of PCNT2 and DBZ with schizophrenia and bipolar disorder in a case-control study of Japanese cohorts, was examined. PMID: 19191256
    27. results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of major depressive disorder in the Japanese population PMID: 19448849
    28. Results show that a lack of microcephalin or pericentrin results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B-Cdk1. PMID: 19546241

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
  • 組織特異性：
    Expressed in all tissues tested, including placenta, liver, kidney and thymus.
  • 數據庫鏈接：

    HGNC: 16068

    OMIM: 210720

    KEGG: hsa:5116

    STRING: 9606.ENSP00000352572

    UniGene: Hs.474069



主站蜘蛛池模板： 国产精品国语对白露脸在线播放| 少妇av一区二区三区无码| 韩国精品一区二区三区四区 | 精品国产sm最大网免费站| 乱人伦中文字幕成人网站在线| 久久久精品人妻一区二区三区| 秋霞电影网午夜鲁丝片无码| 四川骚妇无套内射舔了更爽| 久久精品国产99国产精2021| 中文在线8资源库| 亚洲精品天天影视综合网| 无套内射chinesehd熟女| 免费无码肉片在线观看| 无码专区人妻系列日韩精品少妇| 日本熟日本熟妇在线视频| 亚洲国产精品成人精品无码区蜜臀| 亚洲精品久久夜色撩人男男小说| 成人免费看片又大又黄| 激情综合激情五月俺也去| 无码人妻在线一区二区三区免费| 日日鲁鲁鲁夜夜爽爽狠狠视频97| √天堂中文www官网在线| 午夜福利18以下勿进免费| 色婷婷亚洲一区二区综合| 亚洲aⅴ无码成人网站国产app| 久久99精品久久久久久齐齐| 中文字幕丰满乱子无码视频| 黑人大荫道bbwbbb高潮潮喷| 国产精品vr专区| 女人和拘做受全程看视频| 久久97久久97精品免视看| 麻豆精品一区二区综合av| 午夜福利体验免费体验区| 日韩免费无码视频一区二区三区| 久久国产乱子伦免费精品| 国产97色在线 | 免费| 中文www天堂| 人妻无码精品久久亚瑟影视| 成品人视频ww入口| 无码av免费一区二区三区a片| 亚洲国产成人第一天堂|