在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PCNT Antibody, Biotin conjugated

  • 中文名稱:
    PCNT兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017627LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PCNT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Centrosome Marker antibody; Ken antibody; Kendrin antibody; KIAA0402 antibody; MOPD2 antibody; PCN antibody; PCNT 2 antibody; PCNT antibody; PCNT B antibody; PCNT_HUMAN antibody; PCNT1 antibody; PCNT2 antibody; PCNTB antibody; PCTN2 antibody; Pericentrin 1 antibody; Pericentrin 2 antibody; Pericentrin 380 antibody; Pericentrin antibody; Pericentrin B antibody; Pericentrin-B antibody; SCKL4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pericentrin protein (250-600AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
  • 基因功能參考文獻:
    1. High pericentrin expression is associated with Disruptive Cilia Formation in down syndrome. PMID: 30100262
    2. we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms PMID: 26231886
    3. PCNT has to be phosphorylated by PLK1 to be a suitable substrate of separase. PMID: 26647647
    4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
    5. The CEP215-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis. PMID: 24466316
    6. Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome. PMID: 23979692
    7. PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II. PMID: 24106199
    8. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
    9. The pericentrin B cleavage is essential for timely centriole disengagement and duplication. PMID: 22722493
    10. Kendrin is a novel and crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. PMID: 22542101
    11. Expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects, was analyzed. PMID: 22552340
    12. The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis. PMID: 22184200
    13. PCNT has a crucial role in tooth development; teeth of a patient with a novel homozygous mutation p.Glu1154X are probably the smallest ever reported. PMID: 21567919
    14. Severe insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital. PMID: 21270239
    15. Microcephalic osteodysplastic primordial dwarfism type II is a genetically homogeneous condition due to loss-of-function of pericentrin. PMID: 19643772
    16. Results found no significant association between the pericentrin gene and schizophrenia in the Japanese population. This gene may not play a major role independently in the etiology of SZ. PMID: 19937158
    17. The NESs and NLS of pericentrin are essential for its subcellular localization and nucleocytoplasmic trafficking during the cell cycle.(Pericentrin) PMID: 20567258
    18. Data suggest that pericentrin may regulate the intracellular distribution and secretion of insulin. PMID: 20676397
    19. CG-NAP and kendrin provide sites for microtubule nucleation in the mammalian centrosome by anchoring gamma-TuRC PMID: 12221128
    20. results confirm that MT1-MMP cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP functionality PMID: 16251193
    21. Elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder. PMID: 17884020
    22. Mutations in PCNT cause Seckel syndrome with defective ATR-dependent DNA damage signaling. PMID: 18157127
    23. study found that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) in 25 patients PMID: 18174396
    24. Upregulation of pericentrin is associated with increased angiogenesis and prostate tumor cell proliferation PMID: 18701509
    25. These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics. PMID: 18955030
    26. The association of PCNT2 and DBZ with schizophrenia and bipolar disorder in a case-control study of Japanese cohorts, was examined. PMID: 19191256
    27. results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of major depressive disorder in the Japanese population PMID: 19448849
    28. Results show that a lack of microcephalin or pericentrin results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B-Cdk1. PMID: 19546241

    顯示更多

    收起更多

  • 相關疾病:
    Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
  • 組織特異性:
    Expressed in all tissues tested, including placenta, liver, kidney and thymus.
  • 數據庫鏈接:

    HGNC: 16068

    OMIM: 210720

    KEGG: hsa:5116

    STRING: 9606.ENSP00000352572

    UniGene: Hs.474069



主站蜘蛛池模板: 天堂网在线最新版www资源网| 中国china露脸自拍性hd| 亚洲色成人中文字幕网站| 无码中文字幕日韩专区| 日本一区二区a√成人片| 国产成av人片久青草影院| 国产精品99久久99久久久动漫| 日本不卡高字幕在线2019| 国产精品人妻久久毛片| 狠狠色色综合站| 成人试看120秒体验区| 69久久精品无码一区二区| 久久久久久久岛国免费观看| h漫全彩纯肉无码网站| 亚洲一区二区三区小说| 亚洲男女羞羞无遮挡久久丫| 色噜噜狠狠色综合网| 国产三级在线观看播放视频| 18禁在线永久免费观看| 自拍偷在线精品自拍偷99| 国产女人天天春夜夜春| 国产成人综合色就色综合| 免费无码国产v片在线观看 | 国产老妇伦国产熟女老妇视频| 伊在人天堂亚洲香蕉精品区| 国产成人一区二区三区免费视频 | 久久久久成人片免费观看r| 欧美精品黑人粗大免费| 玩超薄丝袜人妻的经历| 麻花豆传媒剧国产免费mv入口| 曰本一道本久久88不卡| 男女啪啪高清无遮挡免费| 国内少妇毛片视频| 在线亚洲日产一区二区| 欧美日韩精品一区二区性色a+v | 中文字幕人妻丝袜成熟乱| 黑人巨大精品欧美黑寡妇| 色综合久久久久无码专区| 国产卡一卡二卡三卡免费| 国产乱xxⅹxx国语对白| 日韩免费特黄一二三区|