在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PC Antibody

PC Antibody

  • 中文名稱：
    PC兔多克隆抗體
  • 貨號：
    CSB-PA017511GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    mitochondrial antibody; OTTHUMP00000235155 antibody; OTTHUMP00000235156 antibody; PC antibody; PCB antibody; Pcx antibody; PYC_HUMAN antibody; Pyruvate carboxylase antibody; Pyruvate carboxylase mitochondrial antibody; Pyruvic carboxylase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
  • 基因功能參考文獻：
    1. PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. PMID: 27890529
    2. breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. PMID: 27732858
    3. Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
    4. PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets PMID: 25243911
    5. These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. PMID: 25607840
    6. Increased PC expression is correlated with the malignant progression of GC, which might be a potential target for GC biotherapy. PMID: 23294723
    7. characterization of PC distal promoter PMID: 23383084
    8. PC protein is easily detectable by streptavidin blot and the presence of considerable amounts of PC in cultured human myotubes and in human muscle tissue was shown. PMID: 20807508
    9. IVS15+2-5delTAGG results in the retention of intron 15 during pre-mRNA splicing and frameshift mutations. PMID: 12112657
    10. expression and characterization of a variant by retroviral gene transfer PMID: 12437512
    11. 1 deficiency patient survived from neonatal lactic acidemia and shows an unusual subcortical leucodystrophic process. PMID: 16325442
    12. The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported. PMID: 18297087
    13. Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients. PMID: 18676167
    14. The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    15. Nine novel mutations of the PC gene, in five unrelated patients, are reported. PMID: 19306334

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Pyruvate carboxylase deficiency (PC deficiency)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 數據庫鏈接：

    HGNC: 8636

    OMIM: 266150

    KEGG: hsa:5091

    STRING: 9606.ENSP00000377527

    UniGene: Hs.89890



主站蜘蛛池模板： 亚洲中文字幕a∨在线| 欧美黑人巨大videos精品| 毛片免费视频观看| 亚洲成在人线av| 亚洲另类无码专区国内精品| 色九月亚洲综合网| 国产亚洲日韩一区二区三区| 成年女人毛片免费观看97| 国产精品久久久久野外| 香蕉在线精品视频在线| 国产高清女同学巨大乳在线观看| 欧美又黄又大又爽a片三年片 | 黑人玩弄人妻中文在线| 人妻夜夜爽天天爽三区| 一本大道一卡2卡三卡4卡国产| 欧美日产欧美日产国产精品| 苍井空一区二区波多野结衣av | 成人网站免费观看| 久久综合九色综合欧美婷婷| 欧美日本特级婬片视频| 人妻av中文字幕无码专区| 婷婷四房综合激情五月| 欧美专区日韩视频人妻| 五 月 丁 香 综合中文| 女人被黑人狂躁c到高潮小说| 国产精品国色综合久久| av中文无码乱人伦在线观看 | 久久久久高潮毛片免费全部播放| 久久99亚洲精品久久99果| 中国熟妇牲交视频| 无码国产玉足脚交极品网站| 久久久久久久女国产乱让韩| 欧美成人猛片aaaaaaa| 国产又色又爽又黄的视频在线| 成 人 免 费 黄 色| 人妻熟女一区二区aⅴ向井蓝| 国产sm主人调教女m视频| 亚洲欧洲无码av不卡在线| 欧美日韩一本的免费高清视频| 亚洲中文字幕无码中文字| 大肉大捧一进一出好爽视频动漫 |