在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PC Antibody

  • 中文名稱:
    PC兔多克隆抗體
  • 貨號:
    CSB-PA017511GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    mitochondrial antibody; OTTHUMP00000235155 antibody; OTTHUMP00000235156 antibody; PC antibody; PCB antibody; Pcx antibody; PYC_HUMAN antibody; Pyruvate carboxylase antibody; Pyruvate carboxylase mitochondrial antibody; Pyruvic carboxylase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PC
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
  • 基因功能參考文獻:
    1. PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. PMID: 27890529
    2. breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. PMID: 27732858
    3. Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
    4. PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets PMID: 25243911
    5. These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. PMID: 25607840
    6. Increased PC expression is correlated with the malignant progression of GC, which might be a potential target for GC biotherapy. PMID: 23294723
    7. characterization of PC distal promoter PMID: 23383084
    8. PC protein is easily detectable by streptavidin blot and the presence of considerable amounts of PC in cultured human myotubes and in human muscle tissue was shown. PMID: 20807508
    9. IVS15+2-5delTAGG results in the retention of intron 15 during pre-mRNA splicing and frameshift mutations. PMID: 12112657
    10. expression and characterization of a variant by retroviral gene transfer PMID: 12437512
    11. 1 deficiency patient survived from neonatal lactic acidemia and shows an unusual subcortical leucodystrophic process. PMID: 16325442
    12. The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported. PMID: 18297087
    13. Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients. PMID: 18676167
    14. The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    15. Nine novel mutations of the PC gene, in five unrelated patients, are reported. PMID: 19306334

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Pyruvate carboxylase deficiency (PC deficiency)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 數據庫鏈接:

    HGNC: 8636

    OMIM: 266150

    KEGG: hsa:5091

    STRING: 9606.ENSP00000377527

    UniGene: Hs.89890



主站蜘蛛池模板: 欧美丰满大乳高跟鞋| 鲁丝一区二区三区免费| 婷婷五月综合色视频| 无码中文人妻在线三区| 国产在线观看高清视频黄网| 久久久久久久精品成人热色戒汤唯| 亚洲精品永久在线观看| 日韩在线一区二区三区免费视频| 国精品午夜福利视频| 成人国产精品秘片多多| 国产免费艾彩sm调教视频| 欧美性猛交xxxx乱大交丰满| 日本一道一区二区视频| 亚洲hdmi高清线| 麻豆网神马久久人鬼片| 男女真人国产牲交a做片野外| 无码中文字幕免费一区二区三区 | 婷婷伊人五月尤物| 国产成人久久精品77777综合| 国产亚洲精品a在线| 加勒比中文字幕无码一区| 极品少妇被猛的白浆直喷白浆| 中国女人内谢69xxxxxa片| 玩弄放荡人妇系列av在线网站| 亚洲色欲色欲www成人网| 久久精品久久精品久久39| 少妇愉情理伦片高潮日本| 国产精品96久久久久久av网址| 国产在线不卡精品网站| 免费ā片在线观看| 韩国精品无码少妇在线观看| 先锋影音av最新资源| 欧美人与动牲猛交a欧美精品| 亚洲欧美国产毛片在线| 狠狠狠色丁香综合婷婷久久 | 波多野结衣不打码视频| 全部孕妇毛片| 男女做爰猛烈啪啪吃奶动| 无码国产精品一区二区免费16| 国产96在线 | 欧美| 久久无码国产专区精品|