在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PC Antibody, Biotin conjugated

  • 中文名稱:
    PC兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA017511LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    mitochondrial antibody; OTTHUMP00000235155 antibody; OTTHUMP00000235156 antibody; PC antibody; PCB antibody; Pcx antibody; PYC_HUMAN antibody; Pyruvate carboxylase antibody; Pyruvate carboxylase mitochondrial antibody; Pyruvic carboxylase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Pyruvate carboxylase, mitochondrial protein (773-1007AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
  • 基因功能參考文獻:
    1. PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. PMID: 27890529
    2. breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. PMID: 27732858
    3. Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
    4. PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets PMID: 25243911
    5. These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. PMID: 25607840
    6. Increased PC expression is correlated with the malignant progression of GC, which might be a potential target for GC biotherapy. PMID: 23294723
    7. characterization of PC distal promoter PMID: 23383084
    8. PC protein is easily detectable by streptavidin blot and the presence of considerable amounts of PC in cultured human myotubes and in human muscle tissue was shown. PMID: 20807508
    9. IVS15+2-5delTAGG results in the retention of intron 15 during pre-mRNA splicing and frameshift mutations. PMID: 12112657
    10. expression and characterization of a variant by retroviral gene transfer PMID: 12437512
    11. 1 deficiency patient survived from neonatal lactic acidemia and shows an unusual subcortical leucodystrophic process. PMID: 16325442
    12. The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported. PMID: 18297087
    13. Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients. PMID: 18676167
    14. The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    15. Nine novel mutations of the PC gene, in five unrelated patients, are reported. PMID: 19306334

    顯示更多

    收起更多

  • 相關疾病:
    Pyruvate carboxylase deficiency (PC deficiency)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 數據庫鏈接:

    HGNC: 8636

    OMIM: 266150

    KEGG: hsa:5091

    STRING: 9606.ENSP00000377527

    UniGene: Hs.89890



主站蜘蛛池模板: 人妻少妇精品久久| 99久久国产精品免费高潮| 国色精品卡一卡2卡3卡4卡在线| 欧美日韩精品成人网站二区 | 好吊妞国产欧美日韩免费观看| 国产h视频在线观看| 国产99视频精品免费专区 | 国产av麻豆天堂亚洲国产av刚刚碰| 亚洲色精品三区二区一区| 午夜片无码区私人影院| 无码人妻品一区二区三区精99| 被技师按摩到高潮的少妇| 国产亚洲精品久久一区二区| 男男车车的车车网站w98免费| 久久综合狠狠色综合伊人| 欧洲亚洲1卡二卡三卡2021 | 欧美性黑人极品hd| 亚洲精品无码不卡在线播he| 开心五月色婷婷综合开心网| 在线亚洲欧美日韩精品专区| 人妻 偷拍 无码 中文字幕| 精品无码成人片一区二区98| 特级av毛片免费观看| 84pao国产成视频永久免费| 日本免费人成在线观看网站| 国产xxxx99真实实拍| 成人性生交大片免费| 少妇被爽到高潮在线观看| 97久久超碰国产精品旧版麻豆| 内射白浆一区二区在线观看 | 又色又爽又高潮免费视频观看| 无尺码精品产品视频| 久久青青草原精品国产app| 99re久久精品国产首页| 天天射寡妇射| 婷婷久久香蕉五月综合| 国产va免费精品观看| 国产在热线精品视频| 人妻熟女一区二区aⅴ向井蓝| 五月婷婷之综合缴情| 国产无遮挡a片无码免费软件|