在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PAK3 Antibody

PAK3 Antibody

  • 中文名稱：
    PAK3兔多克隆抗體
  • 貨號：
    CSB-PA020233
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human PAKβ around the non-phosphorylation site of S154.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
  • 基因功能參考文獻：
    1. The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. PMID: 29169729
    2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
    3. This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
    4. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. PMID: 25666757
    5. Cdc42Hs binds to the effector domain of PAK3 PMID: 25109462
    6. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
    7. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    8. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid PMID: 20960100
    9. PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. The MRX30 mutation might contribute to the cognitive deficits underlying this form of X-linked mental retardation. PMID: 15574732
    10. PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. PMID: 18523455
    11. PAK3 codes for a splice variant that contains a 45-bp alternatively spliced exon. The exon encodes 15 aa that are inserted in the regulatory domain. PAK3b displays a high kinase activity in starved cells that is not further stimulated by active GTPases. PMID: 12464619

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, X-linked 30 (MRX30)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
  • 數據庫鏈接：

    HGNC: 8592

    OMIM: 300142

    KEGG: hsa:5063

    STRING: 9606.ENSP00000353864

    UniGene: Hs.593599



主站蜘蛛池模板： 亚洲成av人在线观看网站| 国产精品日韩欧美一区二区三区| 国产热の有码热の无码视频| 亚洲精品蜜夜内射| 88国产精品欧美一区二区三区| 国产高清无套内谢| 好了av四色综合无码久久| 日韩欧国产精品一区综合无码| 久9视频这里只有精品试看| 99久久99久久免费精品蜜桃 | 精品人妻av区| 国产乱码人妻一区二区三区四区| 国产 高清 无码 在线播放| 极品粉嫩福利午夜在线播放| 国产精品99久久久久久宅男小说| 日本一区二区三区免费高清| 精品国产乱码久久久久久郑州公司| 国产av夜夜欢一区二区三区| 国产视频亚洲精品视频| 艳妇乳肉豪妇荡乳在线观看| 久久精品无码一区二区三区免费| 亚洲免费观看在线视频| 日韩精品一区二区三区中文| 国产白嫩护士在线播放| 亚洲色成人影院在线观看| 日欧一片内射va在线影院| 国产精品一区二区久久| 大帝av在线一区二区三区| 日韩av无码一区二区三区无码| 在线观看片a免费不卡观看| 中文无码乱人伦中文视频在线v| 国产日产欧洲无码视频| 无码手机线免费观看| 国产男女免费完整视频网页| 中文无码vr最新无码av专区| 欧洲多毛裸体xxxxx| 国产人妻精品区一区二区三区 | 亚欧av无码乱码在线观看性色| 6080yyy午夜理论片中无码| 性色a∨精品高清在线观看| 国产与黑人在线播放|