在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PAK3 Antibody, HRP conjugated

PAK3 Antibody, HRP conjugated

  • 中文名稱：
    PAK3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA017407LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PAK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
  • 基因功能參考文獻：
    1. The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. PMID: 29169729
    2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
    3. This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
    4. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. PMID: 25666757
    5. Cdc42Hs binds to the effector domain of PAK3 PMID: 25109462
    6. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
    7. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    8. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid PMID: 20960100
    9. PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. The MRX30 mutation might contribute to the cognitive deficits underlying this form of X-linked mental retardation. PMID: 15574732
    10. PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. PMID: 18523455
    11. PAK3 codes for a splice variant that contains a 45-bp alternatively spliced exon. The exon encodes 15 aa that are inserted in the regulatory domain. PAK3b displays a high kinase activity in starved cells that is not further stimulated by active GTPases. PMID: 12464619

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Mental retardation, X-linked 30 (MRX30)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
  • 數據庫鏈接：

    HGNC: 8592

    OMIM: 300142

    KEGG: hsa:5063

    STRING: 9606.ENSP00000353864

    UniGene: Hs.593599



主站蜘蛛池模板： 99久久无色码中文字幕人妻| 国产精品自在线拍国产手机版| 日本妇人成熟免费| 蜜臀av99无码精品国产专区| 97se狼狼狼狼狼亚洲网| 亚洲成a人无码| 国产一区二区精品丝袜| 久久97国产超碰青草| 久欠精品国国产99国产精2021| 国内嫩模私拍精品视频| 国产suv精品一区| 亚洲一区二区无码偷拍| 亚洲乱码卡一卡二卡新区仙踪木木| 色五月丁香六月欧美综合| 免费人成在线观看视频播放| 国产亚洲精品欧洲在线视频| 乱色国内精品视频在线| 久久久精品人妻一区二区三区蜜桃 | 无码国内精品久久人妻蜜桃| 日韩放荡少妇无码视频| 波多野结av在线无码中文| 欧美无遮挡很黄裸交视频| 四虎国产精品永久在线| 欧美丰满肥婆videos| 顶级欧美做受xxx000| 隔壁人妻偷人bd中字| 夜夜爱夜夜做夜夜爽| 亚洲欧美日韩综合一区在线| 奶头好大狂揉60分钟视频| 脱岳裙子从后面挺进去在线观看| 青青久在线视观看视| 天堂资源在线www在线观看| 成人无码免费一区二区三区| 国产成人久久a免费观看| 久久国产精品人妻丝袜| 日日碰狠狠躁久久躁| 真人抽搐一进一出gif| 无码中出人妻中文字幕av| 亚洲男同gv在线观看| 国产精品久久久天天影视| 天堂网www在线资源最新版|