在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PAK3 (Ab-154) Antibody

PAK3 (Ab-154) Antibody

  • 中文名稱：
    PAK3 (Ab-154)兔多克隆抗體
  • 貨號：
    CSB-PA554964
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from rat heart, using PAK3 (Ab-154) antibody.
    • Western blot analysis of extracts from HeLa cells (Lane 2), using PAK3 (Ab-154) antiobdy. The lane on the left is treated with systhesized peptide.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PAK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human PAK3 around the phosphorylation site of serine 154 (Y-M-S(p)-F-T).
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
  • 基因功能參考文獻：
    1. The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. PMID: 29169729
    2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
    3. This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
    4. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. PMID: 25666757
    5. Cdc42Hs binds to the effector domain of PAK3 PMID: 25109462
    6. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
    7. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    8. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid PMID: 20960100
    9. PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. The MRX30 mutation might contribute to the cognitive deficits underlying this form of X-linked mental retardation. PMID: 15574732
    10. PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. PMID: 18523455
    11. PAK3 codes for a splice variant that contains a 45-bp alternatively spliced exon. The exon encodes 15 aa that are inserted in the regulatory domain. PAK3b displays a high kinase activity in starved cells that is not further stimulated by active GTPases. PMID: 12464619

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, X-linked 30 (MRX30)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
  • 數據庫鏈接：

    HGNC: 8592

    OMIM: 300142

    KEGG: hsa:5063

    STRING: 9606.ENSP00000353864

    UniGene: Hs.593599



主站蜘蛛池模板： 免费大香伊蕉在人线国产卡| 欧美黑人巨大videos精品| 色妞ww精品视频7777| 国色天香中文字幕在线视频| 看全色黄大色大片免费久久| 国产-第1页-浮力影院| 久久久欧美精品激情| 人人妻人人爽人人澡欧美一区| 欧美成人看片一区二三区图文| 九九久久精品国产免费看小说| 婷婷丁香五月缴情视频| 女人被狂躁的高潮免费视频| 一区二区三区无码被窝影院| 国产精品不卡无码av在线播放| 亚洲精品一区二区丝袜图片| 精品国产亚洲午夜精品av| 国产av一二三无码影片| 久久久久国产精品免费免费搜索| 夜夜未满十八勿进的爽爽影院| 青青青国产免a在线观看| 日本一卡2卡三卡4卡免费网站 | 人妻免费一区二区三区最新| 国产传媒麻豆剧精品av国产| 国产成人愉拍免费视频| 男女下面一进一出无遮挡| 久久综合亚洲色一区二区三区| 欧美深性狂猛ⅹxxx深喉| 成 人色 网 站 欧美大片在线观看 | 日日躁夜夜躁狠狠躁超碰97| 亚洲精品成人无码中文毛片| 国产无遮挡乱子伦免费精品| 久久久97丨国产人妻熟女| 久久精品国产成人av| 国产精品久久久久9999小说| 超碰97人人做人人爱亚洲| 色伦专区97中文字幕| 欧美日韩一区二区三区在线观看视频| 久久天天躁狠狠躁夜夜网站| 亚洲国产精品一区二区久久| 亚洲高潮喷水无码av电影| 中文字幕亚洲码在线|