在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PAG1 Antibody

  • 中文名稱:
    PAG1兔多克隆抗體
  • 貨號:
    CSB-PA885746LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA885746LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA885746LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA885746LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse lung tissue
      All lanes: PAG1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PAG1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PAG1
  • 別名:
    CBP antibody; Csk binding protein antibody; Csk-binding protein antibody; FLJ37858 antibody; MGC138364 antibody; PAG 1 antibody; PAG antibody; PAG1 antibody; PAG1_HUMAN antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains antibody; Phosphoprotein associated with glycosphingolipid microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 antibody; Protein Associated with Glycosphingolipid Enriched Microdomains antibody; Transmembrane adapter protein PAG antibody; Transmembrane phosphoprotein Cbp antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein (97-432AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PAG1 Antibody (CSB-PA885746LA01HU),的標記方式是Non-conjugated。對于PAG1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA885746LB01HU PAG1 Antibody, HRP conjugated ELISA
    FITC CSB-PA885746LC01HU PAG1 Antibody, FITC conjugated
    Biotin CSB-PA885746LD01HU PAG1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
  • 基因功能參考文獻:
    1. Low PAG1 expression is associated neuroblastoma. PMID: 26993602
    2. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways. PMID: 29079189
    3. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis PMID: 26062415
    4. No association Pag1 mutation with patient with Schizophrenia. PMID: 25005592
    5. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect. PMID: 26211970
    6. CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. PMID: 25684946
    7. The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth. PMID: 23671581
    8. siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death. PMID: 22994656
    9. expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression. PMID: 22027792
    10. findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells PMID: 22659621
    11. An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK, as well as the cyclin D1 expression, leading to an inhibition of the proliferation ability of tumor cells. PMID: 21092590
    12. Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells. PMID: 21388951
    13. Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. PMID: 21156787
    14. PAG1 protein was downregulated in PC-3M-1E8 prostate cancer cell line. PMID: 20388373
    15. In the membrane environment of ALK+ lymphoma rafts, where the glycosphingolipid to signaling protein ratio is higher than in B-NHL rafts, the Lyn activity is suboptimal and does not allow the formation of an efficient Lyn-Cbp/PAG signalosome PMID: 20561033
    16. Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner. PMID: 16636672
    17. High PAG-binding ability with CSK in vitro as well as the human PAG structure characterized by 11 alpha-helix structures including a 3 kDa transmembrane domain are reported. PMID: 16947079
    18. PAG negatively regulates Ras proteins, and by knocking down PAG there is enhanced Src kinase activity and Ras activation. PMID: 17389760
    19. engagement of the SH2 domain on PAG renders FynT insensitive to Csk negative regulation PMID: 18056706
    20. role in control of proliferation and survival in most B-non-Hodgkin lymphomas PMID: 18070987
    21. new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis PMID: 19581936

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 組織特異性:
    Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
  • 數據庫鏈接:

    HGNC: 30043

    OMIM: 605767

    KEGG: hsa:55824

    STRING: 9606.ENSP00000220597

    UniGene: Hs.266175



主站蜘蛛池模板: 日产日韩亚洲欧美综合下载| 男女高潮又爽又黄又无遮挡| 边吃奶边添下面好爽| 特黄 做受又硬又粗又大视频| 好日子在线观看视频大全免费动漫| 婷婷丁香六月激情综合啪| av天堂午夜精品一区| 99久久人妻无码精品系列| 精品麻豆一区二区三区乱码| 精品熟女少妇av久久免费软件| 欧美午夜精品一区二区蜜桃| 老外和中国女人毛片免费视频| 色8激情欧美成人久久综合电影| 久久亚洲欧美国产精品| 色偷偷人人澡人人爽人人模| 女人被狂躁60分钟视频| 无码中文人妻在线一区| 国产av无码专区亚洲aⅴ| 国产精品久久久久久福利| 色又黄又爽18禁免费网站现观看| 欧美国产激情一区二区在线| 成人做爰www网站视频下载| 国产超碰人人爽人人做人人添| 中文字幕乱码无码人妻系列蜜桃| 久久亚洲道色综合久久| 欧美黑人激情性久久| 又色又爽又高潮免费视频观看| 无码人妻一区二区三区免费| 久久精品成人免费国产片小草| 亚洲国产人在线播放首页| 久久天天躁夜夜躁狠狠85麻豆 | 国产传媒精品1区2区3区| 国产涩涩视频在线观看| 一二三四视频社区在线| 日本伦奷在线播放| 狠狠躁18三区二区一区| 高清一区二区三区日本久| 肉感饱满中年熟妇日本| 妲己丰满人熟妇大尺度人体艺| 久久国产欧美日韩精品| 亚洲伊人丝袜精品久久|