在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PAG1 Antibody, HRP conjugated

  • 中文名稱:
    PAG1兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA885746LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PAG1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PAG1
  • 別名:
    CBP antibody; Csk binding protein antibody; Csk-binding protein antibody; FLJ37858 antibody; MGC138364 antibody; PAG 1 antibody; PAG antibody; PAG1 antibody; PAG1_HUMAN antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains antibody; Phosphoprotein associated with glycosphingolipid microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 antibody; Protein Associated with Glycosphingolipid Enriched Microdomains antibody; Transmembrane adapter protein PAG antibody; Transmembrane phosphoprotein Cbp antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein (97-432AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
  • 基因功能參考文獻:
    1. Low PAG1 expression is associated neuroblastoma. PMID: 26993602
    2. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways. PMID: 29079189
    3. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis PMID: 26062415
    4. No association Pag1 mutation with patient with Schizophrenia. PMID: 25005592
    5. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect. PMID: 26211970
    6. CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. PMID: 25684946
    7. The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth. PMID: 23671581
    8. siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death. PMID: 22994656
    9. expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression. PMID: 22027792
    10. findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells PMID: 22659621
    11. An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK, as well as the cyclin D1 expression, leading to an inhibition of the proliferation ability of tumor cells. PMID: 21092590
    12. Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells. PMID: 21388951
    13. Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. PMID: 21156787
    14. PAG1 protein was downregulated in PC-3M-1E8 prostate cancer cell line. PMID: 20388373
    15. In the membrane environment of ALK+ lymphoma rafts, where the glycosphingolipid to signaling protein ratio is higher than in B-NHL rafts, the Lyn activity is suboptimal and does not allow the formation of an efficient Lyn-Cbp/PAG signalosome PMID: 20561033
    16. Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner. PMID: 16636672
    17. High PAG-binding ability with CSK in vitro as well as the human PAG structure characterized by 11 alpha-helix structures including a 3 kDa transmembrane domain are reported. PMID: 16947079
    18. PAG negatively regulates Ras proteins, and by knocking down PAG there is enhanced Src kinase activity and Ras activation. PMID: 17389760
    19. engagement of the SH2 domain on PAG renders FynT insensitive to Csk negative regulation PMID: 18056706
    20. role in control of proliferation and survival in most B-non-Hodgkin lymphomas PMID: 18070987
    21. new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis PMID: 19581936

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 組織特異性:
    Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30043

    OMIM: 605767

    KEGG: hsa:55824

    STRING: 9606.ENSP00000220597

    UniGene: Hs.266175



主站蜘蛛池模板: 天堂在/线中文在线资源8| 一区二区国产精品精华液| 丰满大爆乳波霸奶| 97se亚洲综合自在线| 色婷婷五月综合色啪网| 99精品国产免费观看视频| 久久无码av中文出轨人妻| 18禁区美女免费观看网站| 久久九九国产精品怡红院| 天天摸日日摸狠狠添| 色偷偷av一区二区三区| av无码中文字幕不卡一区二区三区| 国产成人欧美一区二区三区| 国产精品伦一区二区三级视频| 国产超碰人人爱被ios解锁| 色惰日本视频网站www| 日本丰满熟妇hd| 中文久久乱码一区二区| 玩弄放荡人妇系列av在线网站| 99爱在线精品视频免费观看| 久久午夜神器| 亚洲色欲久久久久综合网| 人妻护士在线波多野结衣| 欧美xxxx欧美精品| 超清av在线播放不卡无码| 亚洲小说图区综合在线| 97色伦午夜国产亚洲精品| 亚洲精品中文字幕无码蜜桃| 亚洲精品久久久蜜桃| 亚洲日韩在线a视频在线观看 | 久青草久青草视频在线观看 | 人人妻人人澡人人爽人人精品av| 亚洲 丝袜 制服 欧美 另类 | 重口sm一区二区三区视频| 国产av国片精品有毛| 中国极品少妇xxxxx| 先锋影音xfyy5566男人资源| 中文字幕日韩人妻不卡一区| 国产真实老熟女无套内射| 国产一区二区三区影院| 又爽又黄又无遮挡网站|