在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PAG1 Antibody, FITC conjugated

  • 中文名稱:
    PAG1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA885746LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PAG1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PAG1
  • 別名:
    CBP antibody; Csk binding protein antibody; Csk-binding protein antibody; FLJ37858 antibody; MGC138364 antibody; PAG 1 antibody; PAG antibody; PAG1 antibody; PAG1_HUMAN antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains antibody; Phosphoprotein associated with glycosphingolipid microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 antibody; Protein Associated with Glycosphingolipid Enriched Microdomains antibody; Transmembrane adapter protein PAG antibody; Transmembrane phosphoprotein Cbp antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein (97-432AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
  • 基因功能參考文獻:
    1. Low PAG1 expression is associated neuroblastoma. PMID: 26993602
    2. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways. PMID: 29079189
    3. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis PMID: 26062415
    4. No association Pag1 mutation with patient with Schizophrenia. PMID: 25005592
    5. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect. PMID: 26211970
    6. CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. PMID: 25684946
    7. The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth. PMID: 23671581
    8. siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death. PMID: 22994656
    9. expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression. PMID: 22027792
    10. findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells PMID: 22659621
    11. An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK, as well as the cyclin D1 expression, leading to an inhibition of the proliferation ability of tumor cells. PMID: 21092590
    12. Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells. PMID: 21388951
    13. Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. PMID: 21156787
    14. PAG1 protein was downregulated in PC-3M-1E8 prostate cancer cell line. PMID: 20388373
    15. In the membrane environment of ALK+ lymphoma rafts, where the glycosphingolipid to signaling protein ratio is higher than in B-NHL rafts, the Lyn activity is suboptimal and does not allow the formation of an efficient Lyn-Cbp/PAG signalosome PMID: 20561033
    16. Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner. PMID: 16636672
    17. High PAG-binding ability with CSK in vitro as well as the human PAG structure characterized by 11 alpha-helix structures including a 3 kDa transmembrane domain are reported. PMID: 16947079
    18. PAG negatively regulates Ras proteins, and by knocking down PAG there is enhanced Src kinase activity and Ras activation. PMID: 17389760
    19. engagement of the SH2 domain on PAG renders FynT insensitive to Csk negative regulation PMID: 18056706
    20. role in control of proliferation and survival in most B-non-Hodgkin lymphomas PMID: 18070987
    21. new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis PMID: 19581936

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 組織特異性:
    Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
  • 數據庫鏈接:

    HGNC: 30043

    OMIM: 605767

    KEGG: hsa:55824

    STRING: 9606.ENSP00000220597

    UniGene: Hs.266175



主站蜘蛛池模板: 制服丝袜有码中文字幕在线| 亚洲精品tv久久久久久久久久| 日韩av无码中文无码不卡电影| 人妻丰满熟妇av无码区不卡| 国产v综合v亚洲欧美久久| 青草青在线视频在线观看| 亚洲国产日韩a在线播放| 嫩草av久久伊人妇女超级a| 中文字幕丰满乱子伦无码专区| 精品国精品无码自拍自在线| 免费毛片a线观看| 久久青草成人综合网站| 国产av综合第一页| 又色又爽又黄的视频网站| 少妇三级全黄| 中文无码字幕中文有码字幕| 国产av偷闻女邻居内裤被发现| 四虎成人精品永久在线视频| 小荡货好紧好爽奶头大视频| 亚洲精品亚洲人成在线| 丰满日韩放荡少妇无码视频 | 在线视频免费无码专区| 性生交片免费无码看人| 特黄特色大片免费播放| 亚洲一卡2卡3卡4卡 精品| 亚洲中文字幕无码卡通动漫野外| 国产精品免费久久久久影院仙踪林| 成人毛片无码一区二区三区| 免费国产h视频在线观看| 亚洲国产欧美在线观看片不卡| 肉色超薄丝袜脚交一区二区| 美女裸体十八禁免费网站| 日韩卡二卡三卡四卡永久入口| 国产大陆亚洲精品国产| 精品久久久久久国产| 女乱高潮久久久久久爽爽| 久久精品国产亚洲不av麻豆| 熟妇人妻系列aⅴ无码专区友真希| 台湾佬中文娱乐22vvvv| 天天摸天天做天天爽天天弄| 欧美性狂猛xxxxx深喉|