在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NTMT1 Antibody

  • 中文名稱:
    NTMT1兔多克隆抗體
  • 貨號:
    CSB-PA013725GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AD 003 antibody; Alpha N-terminal protein methyltransferase 1A antibody; C9orf32 antibody; Chromosome 9 open reading frame 32 antibody; Methyltransferase like 11A antibody; Methyltransferase-like protein 11A antibody; Mettl11a antibody; N-terminal RCC1 methyltransferase antibody; NRMT antibody; NTM1A antibody; NTM1A_HUMAN antibody; NTMT1 antibody; X-Pro-Lys N-terminal protein methyltransferase 1A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human METTL11A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
  • 基因功能參考文獻:
    1. CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. PMID: 28266506
    2. NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. PMID: 28556566
    3. These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. PMID: 25843235
    4. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. PMID: 26543159
    5. kinetic mechanism of NTMT1 PMID: 25771539
    6. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
    7. Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. PMID: 22769851
    8. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Predominantly nuclear (PubMed:24090352).
  • 蛋白家族:
    Methyltransferase superfamily, NTM1 family
  • 數據庫鏈接:

    HGNC: 23373

    OMIM: 613560

    KEGG: hsa:28989

    STRING: 9606.ENSP00000361558

    UniGene: Hs.744027



主站蜘蛛池模板: 国产av大陆精品一区二区三区 | 欧美精品一产区二产区| 亚洲人成网亚洲欧洲无码| 国产精品久久久久无码av1| 公么大龟弄得我好舒服秀婷视频| 中文字幕aⅴ人妻一区二区| 青青国产揄拍视频 | 18级成人毛片免费观看| 欧美人与动牲交a精品| 欧美大肥婆大肥bbbbb| 成人免费午夜无码视频在线播放| 成 人 免 费 黄 色| 国产亚洲曝欧美不卡精品| 成熟人妻av无码专区| 精品国产一区二区三区色欲| 日本一区二区无卡高清视频| 久久伊人av综合影院| 天天综合网网欲色| 国产精品色无码av在线观看| 东北老女人高潮大喊舒服死了| 久久精品亚洲中文字幕无码网站| 男女猛烈无遮挡免费视频| 国内精品久久久久影视老司机| 久久久国产99久久国产久一 | 亚洲日本va午夜中文字幕一区| 丰满岳跪趴高撅肥臀尤物在线观看 | 日本久久夜夜一本婷婷| 欧美熟妇性xxx交潮喷| 一区二区国产精品精华液| 欧美性色黄大片www喷水| 中文字幕va一区二区三区| 亚洲色欲色欱www在线| 国产成人麻豆精品午夜福利在线| 一本一本久久a久久综合精品| 天堂中文在线www天堂在线| 日韩精品极品视频在线观看免费 | 菠萝菠萝蜜午夜视频在线播放观看| 亚洲乱码在线卡一卡二卡新区| 欧美肥胖老妇bbw| 重口sm一区二区三区视频| 国产v在线最新观看视频|