在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NTMT1 Antibody

NTMT1 Antibody

  • 中文名稱：
    NTMT1兔多克隆抗體
  • 貨號：
    CSB-PA248105
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA248105(NTMT1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AD 003 antibody; Alpha N-terminal protein methyltransferase 1A antibody; C9orf32 antibody; Chromosome 9 open reading frame 32 antibody; Methyltransferase like 11A antibody; Methyltransferase-like protein 11A antibody; Mettl11a antibody; N-terminal RCC1 methyltransferase antibody; NRMT antibody; NTM1A antibody; NTM1A_HUMAN antibody; NTMT1 antibody; X-Pro-Lys N-terminal protein methyltransferase 1A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human NTMT1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
  • 基因功能參考文獻：
    1. CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. PMID: 28266506
    2. NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. PMID: 28556566
    3. These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. PMID: 25843235
    4. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. PMID: 26543159
    5. kinetic mechanism of NTMT1 PMID: 25771539
    6. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
    7. Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. PMID: 22769851
    8. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Predominantly nuclear (PubMed:24090352).
  • 蛋白家族：
    Methyltransferase superfamily, NTM1 family
  • 數據庫鏈接：

    HGNC: 23373

    OMIM: 613560

    KEGG: hsa:28989

    STRING: 9606.ENSP00000361558

    UniGene: Hs.744027



主站蜘蛛池模板： 日韩免费无码视频一区二区三区| 在线亚洲专区高清中文字幕| 午夜国产成人片在线播放| 亚洲精品无码专区在线播放| 久久久久99精品成人片| 国产免费永久精品无码| 亚洲成av人片一区二区密柚| 成人国产mv免费视频| 国产精品久久人妻无码网站蜜臀| 无码av喷白浆在线播放| 精品人伦一区二区三电影| 色婷婷美国农夫综合激情亚洲| 国产av综合影院| www国产亚洲精品久久| 极品少妇被猛得白浆直喷白浆小说 | 99精品丰满人妻无码a片| 色偷偷久久一区二区三区| 777米奇色狠狠888俺也去乱| 亚洲精品无码不卡在线播he| 国产精品一区二区在线观看| 国产精品午夜福利不卡| 久久国产欧美成人网站| 国产鲁鲁视频在线观看| 亚洲人精品午夜射精日韩| 亚洲一卡2卡三卡四卡精品 | 国产精品高潮呻吟av久久男男| 色偷偷色噜噜狠狠网站久久| 国产精品亚洲专区无码不卡| 99久久国产精品免费高潮| 日韩精品亚洲色大成网站| av鲁丝一区鲁丝二区鲁丝三区| 天天爽天天爽夜夜爽毛片| 成 人 黄 色 大片| 亚洲成年轻人电影网站www| 久久欧美一区二区三区性生奴| 蜜臀av一区二区| 人妻精品动漫h无码网站| 国产熟妇乱子伦视频在线观看| 色橹橹欧美在线观看视频高清| 国产美女被遭高潮免费视频 | 日本午夜免费啪视频在线|