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NTMT1 Antibody

  • 中文名稱：
    NTMT1兔多克隆抗體
  • 貨號：
    CSB-PA880111HA01HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NTMT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AD 003 antibody; Alpha N-terminal protein methyltransferase 1A antibody; C9orf32 antibody; Chromosome 9 open reading frame 32 antibody; Methyltransferase like 11A antibody; Methyltransferase-like protein 11A antibody; Mettl11a antibody; N-terminal RCC1 methyltransferase antibody; NRMT antibody; NTM1A antibody; NTM1A_HUMAN antibody; NTMT1 antibody; X-Pro-Lys N-terminal protein methyltransferase 1A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-terminal Xaa-Pro-Lys N-methyltransferase 1 protein (1-223AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NTMT1 Antibody (CSB-PA880111HA01HU)，的標記方式是Non-conjugated。對于NTMT1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA880111HB01HU NTMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA880111HC01HU NTMT1 Antibody, FITC conjugated
    Biotin CSB-PA880111HD01HU NTMT1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
  • 基因功能參考文獻：
    1. CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. PMID: 28266506
    2. NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. PMID: 28556566
    3. These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. PMID: 25843235
    4. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. PMID: 26543159
    5. kinetic mechanism of NTMT1 PMID: 25771539
    6. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
    7. Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. PMID: 22769851
    8. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449

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  • 亞細胞定位：
    Nucleus. Note=Predominantly nuclear (PubMed:24090352).
  • 蛋白家族：
    Methyltransferase superfamily, NTM1 family
  • 數據庫鏈接：

    HGNC: 23373

    OMIM: 613560

    KEGG: hsa:28989

    STRING: 9606.ENSP00000361558

    UniGene: Hs.744027



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