在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NTMT1 Antibody

  • 中文名稱:
    NTMT1兔多克隆抗體
  • 貨號:
    CSB-PA880111HA01HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NTMT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AD 003 antibody; Alpha N-terminal protein methyltransferase 1A antibody; C9orf32 antibody; Chromosome 9 open reading frame 32 antibody; Methyltransferase like 11A antibody; Methyltransferase-like protein 11A antibody; Mettl11a antibody; N-terminal RCC1 methyltransferase antibody; NRMT antibody; NTM1A antibody; NTM1A_HUMAN antibody; NTMT1 antibody; X-Pro-Lys N-terminal protein methyltransferase 1A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human N-terminal Xaa-Pro-Lys N-methyltransferase 1 protein (1-223AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NTMT1 Antibody (CSB-PA880111HA01HU),的標記方式是Non-conjugated。對于NTMT1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA880111HB01HU NTMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA880111HC01HU NTMT1 Antibody, FITC conjugated
    Biotin CSB-PA880111HD01HU NTMT1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
  • 基因功能參考文獻:
    1. CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. PMID: 28266506
    2. NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. PMID: 28556566
    3. These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. PMID: 25843235
    4. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. PMID: 26543159
    5. kinetic mechanism of NTMT1 PMID: 25771539
    6. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
    7. Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. PMID: 22769851
    8. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Predominantly nuclear (PubMed:24090352).
  • 蛋白家族:
    Methyltransferase superfamily, NTM1 family
  • 數據庫鏈接:

    HGNC: 23373

    OMIM: 613560

    KEGG: hsa:28989

    STRING: 9606.ENSP00000361558

    UniGene: Hs.744027



主站蜘蛛池模板: 欧美日韩亚洲国产欧美电影 | 欧美gv在线观看| 无码av免费一区二区三区a片| 国产精品女同一区二区在线| 国产亚洲日韩在线a不卡| 精品成在人线av无码免费看| 中文在线中文资源| 亚洲最大成人综合网720p| 久久无码超清激情av| 97精品尹人久久大香线蕉| 欧美乱大交xxxxx疯狂俱乐部 | 青草青草视频2免费观看| 欧美freesex黑人又粗又大| 亚洲日韩欧美一区二区三区在线| 中文字幕av无码不卡免费| 激情国产av做激情国产爱| 日日碰狠狠丁香久燥| 自拍日韩亚洲一区在线| 亚洲狠狠色成人综合网| 日产精品99久久久久久| 综合亚洲伊人午夜网| 欧洲成人一区二区三区| 欧洲美女黑人粗性暴交视频| 在线看片免费人成视频国产片| 国产精品亚洲二区在线观看| 午夜不卡久久精品无码免费| 色婷婷久久综合中文久久一本| 久久精品人成免费| 最近日本免费观看高清视频| 亚洲国产aⅴ成人精品无吗| 久久人妻无码中文字幕第一| 久久综合色_综合色88| 熟妇高潮一区二区三区| 少女韩国电视剧在线观看完整| 午夜婷婷精品午夜无码a片影院| 日日碰狠狠添天天爽超碰97| 亚洲人成色77777在线观看大战p| 无套内内射视频网站| 久久国产主播福利在线| 久久久国产精品无码一区二区| 潮喷失禁大喷水aⅴ无码|