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  4. MYO18B Antibody

MYO18B Antibody

  • 中文名稱：
    MYO18B兔多克隆抗體
  • 貨號：
    CSB-PA815545LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA815545LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MYO18B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MYO18B
  • 別名：
    BK125H2.1 antibody; DKFZp434C2422 antibody; DKFZp779C1668 antibody; MY18B_HUMAN antibody; MYO18B antibody; myosin 18B antibody; myosin XVIIIB antibody; Myosin-XVIIIb antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Unconventional myosin-XVIIIb protein (370-512AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，MYO18B Antibody (CSB-PA815545LA01HU)，的標(biāo)記方式是Non-conjugated。對于MYO18B Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA815545LB01HU MYO18B Antibody, HRP conjugated ELISA
    FITC CSB-PA815545LC01HU MYO18B Antibody, FITC conjugated
    Biotin CSB-PA815545LD01HU MYO18B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
  • 基因功能參考文獻(xiàn)：
    1. Full loss of myo18b function results in a complete lack of sarcomeric structure, revealing a highly surprising and essential role for myo18b in sarcomere assembly. Importantly, scattered thin and thick filaments assemble throughout the sarcoplasm. These observations suggest a novel model of sarcomere assembly where Myo18b coordinates the integration of preformed thick and thin filaments into the sarcomere PMID: 28104788
    2. Deficiency of MYO18B is linked to a novel developmental disorder which combines KFA with myopathy. PMID: 25748484
    3. No associations were found between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. PMID: 25778778
    4. A common MYO18B variant is associated with mathematical disability in children with dyslexia and with intraparietal sulcus variability in neurotypical adults. PMID: 23423138
    5. candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer PMID: 12209013
    6. Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation PMID: 12547197
    7. MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis PMID: 15305387
    8. Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo. PMID: 16499872
    9. The restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced Malignant pleural mesothelioma(MPM)in humans. PMID: 17294804

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  • 相關(guān)疾病：
    Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism (KFS4)
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性：
    Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18150

    OMIM: 607295

    KEGG: hsa:84700

    STRING: 9606.ENSP00000334563

    UniGene: Hs.417959



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