在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYH6 Antibody

  • 中文名稱:
    MYH6兔多克隆抗體
  • 貨號:
    CSB-PA015299HA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA015299HA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA015299HA01HU diluted at 1:100 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MYH6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    cardiac muscle alpha isoform antibody; MYH6 antibody; MYH6_HUMAN antibody; MYHC antibody; MyHC-alpha antibody; MyHC-beta antibody; MYHCA antibody; MYHCB antibody; Myosin heavy chain 6 antibody; Myosin heavy chain antibody; Myosin heavy chain cardiac muscle alpha isoform antibody; Myosin heavy chain cardiac muscle beta isoform antibody; Myosin-6 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Myosin-6 protein (894-1132AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,MYH6 Antibody (CSB-PA015299HA01HU),的標(biāo)記方式是Non-conjugated。對于MYH6 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA015299HB01HU MYH6 Antibody, HRP conjugated ELISA
    FITC CSB-PA015299HC01HU MYH6 Antibody, FITC conjugated
    Biotin CSB-PA015299HD01HU MYH6 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Muscle contraction.
  • 基因功能參考文獻(xiàn):
    1. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4). PMID: 29505555
    2. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes. PMID: 28431892
    3. The etiology of MYH6-associated HLHS can be informed using iPSCs. PMID: 27789736
    4. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes. PMID: 28991257
    5. the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium PMID: 28088328
    6. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction. PMID: 26085007
    7. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other. PMID: 25937279
    8. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation. PMID: 25717017
    9. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin. PMID: 24224850
    10. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract. PMID: 22627578
    11. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects. PMID: 22194935
    12. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis PMID: 21436590
    13. the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant PMID: 21378987
    14. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism PMID: 20656787
    15. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy. PMID: 20215591
    16. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer. PMID: 19801488
    17. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed PMID: 12933792
    18. Mutation in myosin heavy chain 6 causes atrial septal defect PMID: 15735645
    19. Three heterozygous MYH6 missense mutations were identified in dilated cardiomyopathy probands (P830L, A1004S, and E1457K; 4.3% of probands). A Q1065H mutation was detected in 1 of 21 hypertrophic cardiomyopathy probands. PMID: 15998695
    20. the large step of dimeric myosin VI is primarily made possible by a medial tail in each monomer that forms a rare single alpha-helix of approximately 10 nm, which is anchored to the calmodulin-bound IQ domain by a globular proximal tail. PMID: 18511944

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Atrial septal defect 3 (ASD3); Cardiomyopathy, familial hypertrophic 14 (CMH14); Cardiomyopathy, dilated 1EE (CMD1EE); Sick sinus syndrome 3 (SSS3)
  • 亞細(xì)胞定位:
    Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7576

    OMIM: 160710

    KEGG: hsa:4624

    STRING: 9606.ENSP00000348634

    UniGene: Hs.278432



主站蜘蛛池模板: 浮妇高潮喷白浆视频| 久久亚洲日韩av一区二区三区| 国产成人亚洲日韩欧美| 67194熟妇在线直接进入| 亚洲人成无码网站| 毛片免费全部无码播放| 少妇夜夜春夜夜爽试看视频| 男女做爰无遮挡性视频| 国产成人午夜精华液| 成年轻人电影www无码| 动漫av永久无码精品每日更新| 波多野成人无码精品电影| 人人妻人人澡人人爽人人精品电影| 熟女丰满老熟女熟妇| 男人的天堂av社区在线| 俄罗斯老熟妇色xxxx| 久久久www成人免费无遮挡大片| 天干夜啦天干天干国产免费| 国产杨幂丝袜av在线播放| 五月丁香综合激情六月久久| 艳z门照片无码av| 亚洲国产精品国自产拍电影| 天堂资源在线官网| 久久久久久亚洲精品不卡| 亚洲爆乳www无码专区| 97人人添人澡人人爽超碰| 国产99久久精品一区二区| 丰满岳乱妇在线观看中字无码| 日本在线看片免费人成视频| 熟妇人妻激情偷爽文| 少妇高潮一区二区三区99| 国产xxxxx在线观看| 日日摸日日碰夜夜爽亚洲综合| 亚洲精品一区二区三区中文字幕| 51国产黑色丝袜高跟鞋| 神马午夜福利不卡片在线| 国产亚洲曝欧美不卡精品| 国产一三四2021不卡| 污污又黄又爽免费的网站| 亚洲欧美日韩另类精品一区| 久久久久成人精品免费播放动漫 |