在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYH6 Antibody, HRP conjugated

  • 中文名稱:
    MYH6兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA015299HB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYH6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    cardiac muscle alpha isoform antibody; MYH6 antibody; MYH6_HUMAN antibody; MYHC antibody; MyHC-alpha antibody; MyHC-beta antibody; MYHCA antibody; MYHCB antibody; Myosin heavy chain 6 antibody; Myosin heavy chain antibody; Myosin heavy chain cardiac muscle alpha isoform antibody; Myosin heavy chain cardiac muscle beta isoform antibody; Myosin-6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Myosin-6 protein (894-1132AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Muscle contraction.
  • 基因功能參考文獻:
    1. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4). PMID: 29505555
    2. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes. PMID: 28431892
    3. The etiology of MYH6-associated HLHS can be informed using iPSCs. PMID: 27789736
    4. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes. PMID: 28991257
    5. the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium PMID: 28088328
    6. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction. PMID: 26085007
    7. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other. PMID: 25937279
    8. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation. PMID: 25717017
    9. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin. PMID: 24224850
    10. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract. PMID: 22627578
    11. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects. PMID: 22194935
    12. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis PMID: 21436590
    13. the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant PMID: 21378987
    14. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism PMID: 20656787
    15. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy. PMID: 20215591
    16. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer. PMID: 19801488
    17. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed PMID: 12933792
    18. Mutation in myosin heavy chain 6 causes atrial septal defect PMID: 15735645
    19. Three heterozygous MYH6 missense mutations were identified in dilated cardiomyopathy probands (P830L, A1004S, and E1457K; 4.3% of probands). A Q1065H mutation was detected in 1 of 21 hypertrophic cardiomyopathy probands. PMID: 15998695
    20. the large step of dimeric myosin VI is primarily made possible by a medial tail in each monomer that forms a rare single alpha-helix of approximately 10 nm, which is anchored to the calmodulin-bound IQ domain by a globular proximal tail. PMID: 18511944

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Atrial septal defect 3 (ASD3); Cardiomyopathy, familial hypertrophic 14 (CMH14); Cardiomyopathy, dilated 1EE (CMD1EE); Sick sinus syndrome 3 (SSS3)
  • 亞細胞定位:
    Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數據庫鏈接:

    HGNC: 7576

    OMIM: 160710

    KEGG: hsa:4624

    STRING: 9606.ENSP00000348634

    UniGene: Hs.278432



主站蜘蛛池模板: 日本精品一区二区三区四区| 天堂av无码av在线a√| 国产精品视频在线观看| 国产精品亚洲一区二区| 日本最新免费二区三区| 欧美成人va免费大片视频| 亚洲中文无码av永久伊人| 国产三级精品三级在线专区| 国产精品久久久久久亚洲毛片| 亚洲欧美国产精品久久久久久久| 高清精品一区二区三区| 色欲天天天综合网| 婷婷色五月开心五月| 国产又粗又大又黄| 婷婷久久综合九色综合| 无码高潮喷吹在线观看 | 一本之道高清无码视频| 日本特黄特色特爽大片| 日本www一道久久久免费| 国产放荡对白视频在线观看| 内射合集对白在线| 日本不卡高字幕在线2019| 99久久国产露脸精品国产麻豆| 色偷偷久久一区二区三区| 国产成人精品三级麻豆| 欧美熟妇性开放| 国产国拍亚洲精品av| 国产男女猛烈无遮挡免费视频网站| 日韩中文字幕免费视频| 国产亚洲精品第一综合另类灬| 国产亚洲日韩在线a不卡| 77777_亚洲午夜久久多人| 8天堂资源在线| 动漫av永久无码精品每日更新| 亚洲色国产欧美日韩| 男男啪啪激烈高潮cc漫画免费| 亚洲欧洲日本无在线码| 精品四虎国产在免费观看| 大胆欧美熟妇xx| 日韩人妻中文无码一区二区七区| 色综久久综合桃花网国产精品|