在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYH6 Antibody, FITC conjugated

  • 中文名稱:
    MYH6兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA015299HC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYH6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    cardiac muscle alpha isoform antibody; MYH6 antibody; MYH6_HUMAN antibody; MYHC antibody; MyHC-alpha antibody; MyHC-beta antibody; MYHCA antibody; MYHCB antibody; Myosin heavy chain 6 antibody; Myosin heavy chain antibody; Myosin heavy chain cardiac muscle alpha isoform antibody; Myosin heavy chain cardiac muscle beta isoform antibody; Myosin-6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Myosin-6 protein (894-1132AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Muscle contraction.
  • 基因功能參考文獻:
    1. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4). PMID: 29505555
    2. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes. PMID: 28431892
    3. The etiology of MYH6-associated HLHS can be informed using iPSCs. PMID: 27789736
    4. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes. PMID: 28991257
    5. the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium PMID: 28088328
    6. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction. PMID: 26085007
    7. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other. PMID: 25937279
    8. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation. PMID: 25717017
    9. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin. PMID: 24224850
    10. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract. PMID: 22627578
    11. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects. PMID: 22194935
    12. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis PMID: 21436590
    13. the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant PMID: 21378987
    14. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism PMID: 20656787
    15. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy. PMID: 20215591
    16. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer. PMID: 19801488
    17. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed PMID: 12933792
    18. Mutation in myosin heavy chain 6 causes atrial septal defect PMID: 15735645
    19. Three heterozygous MYH6 missense mutations were identified in dilated cardiomyopathy probands (P830L, A1004S, and E1457K; 4.3% of probands). A Q1065H mutation was detected in 1 of 21 hypertrophic cardiomyopathy probands. PMID: 15998695
    20. the large step of dimeric myosin VI is primarily made possible by a medial tail in each monomer that forms a rare single alpha-helix of approximately 10 nm, which is anchored to the calmodulin-bound IQ domain by a globular proximal tail. PMID: 18511944

    顯示更多

    收起更多

  • 相關疾病:
    Atrial septal defect 3 (ASD3); Cardiomyopathy, familial hypertrophic 14 (CMH14); Cardiomyopathy, dilated 1EE (CMD1EE); Sick sinus syndrome 3 (SSS3)
  • 亞細胞定位:
    Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數據庫鏈接:

    HGNC: 7576

    OMIM: 160710

    KEGG: hsa:4624

    STRING: 9606.ENSP00000348634

    UniGene: Hs.278432



主站蜘蛛池模板: 少妇spa推油被扣高潮| 天天躁日日躁狠狠躁欧美老妇| 免费视频欧美无人区码| 中文字幕亚洲制服在线看| 色综合a怡红院怡红院| 国产高清自产拍av在线| 波多野结衣50连登视频| 日日拍夜夜嗷嗷叫|日日摸| 人妻激情乱人伦| 亚洲最大成人网站| 国产农村乱对白刺激视频| 日韩精品无码人妻一区二区三区| 中文字幕人妻丝袜成熟乱| 精品国产亚洲一区二区三区| 丰满诱人的人妻3| 久久精品囯产精品亚洲| 男人靠女人的免费视频| 鲁丝一区二区三区免费| 亚洲 欧美 成人 自拍 高清| 真实国产乱子伦在线视频| 性欧美大战久久久久久久| 精品人妻无码一区二区三区换脸| 蜜臀久久99精品久久久久久做爰 | 隔壁人妻偷人bd中字| 精品人妻系列无码人妻免费视频| 国产乱人伦偷精品视频下| 亚洲精品鲁一鲁一区二区三区| 熟女体下毛毛黑森林| 成年无码动漫av片在线尤物| 国产成人av在线影院无毒| 亚洲综合图色40p| 亚洲国产av玩弄放荡人妇系列| 亚洲另类欧美在线电影| 九九精品无码专区免费| 无码人妻精品一区二区三区东京热| 日本午夜看x费免| 日本中文一区二区三区亚洲| 中文字幕无码人妻aaa片| 久青草影院在线观看国产| 亚洲伊人久久精品影院| 无码精品视频一区二区三区|