在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MTMR3 Antibody, Biotin conjugated

  • 中文名稱:
    MTMR3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA622675HD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MTMR3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FYVE domain-containing dual specificity protein phosphatase 1 antibody; FYVE-DSP1 antibody; MTMR3 antibody; MTMR3_HUMAN antibody; Myotubularin-related protein 3 antibody; Zinc finger FYVE domain-containing protein 10 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Myotubularin-related protein 3 protein (652-899AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.
  • 基因功能參考文獻:
    1. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
    2. the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR)-induced outcomes, including increased induced caspase-1 activation PMID: 26240347
    3. myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody. PMID: 25659891
    4. cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported PMID: 25195900
    5. These results indicate that MTMR3 may play an important role in the progression of CRC and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC treatment. PMID: 25215329
    6. Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus. PMID: 24943867
    7. Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma. PMID: 24840251
    8. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. PMID: 23154468
    9. MTMR3 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
    10. MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 and MTMR3 PMID: 11846405
    11. A phylogenetic study revealing co-evolution of myotubularins with PI 3-kinase class III complex PMID: 18774718
    12. Autophagosome formation was triggered by the overexpression of a dominant-negative inactive mutant of Myotubularin-related phosphatase 3 (MTMR3). PMID: 20059746
    13. analysis of MTMR3 phosphoinositide binding domain properties PMID: 15840652

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 數據庫鏈接:

    HGNC: 7451

    OMIM: 603558

    KEGG: hsa:8897

    STRING: 9606.ENSP00000384651

    UniGene: Hs.474536



主站蜘蛛池模板: 女人被弄到高潮的免费视频| 一本久道中文无码字幕av| 人妻少妇中文字幕久久| 天堂资源中文网| 色老99久久九九爱精品| 婷婷伊人久久大香线蕉av| 一二三四社区在线中文视频 | 国内精品国产成人国产三级| 国模无码人体一区二区| 潮喷失禁大喷水av无码| 欧美性受xxxx狂喷水| 亚洲精品www久久久久久| 亚洲成a∨人片在无码2023| 特级毛片全部免费播放| av免费网站在线观看| 国产美女自慰在线观看| 人妻丝袜中文无码av影音先锋专区| 国产成 人 综合 亚洲专区| 亚洲熟女av乱码在线观看漫画| 亚洲人成电影网站色www| 熟妇人妻无码中文字幕老熟妇| 国产 高潮 抽搐 正在播放| 国产超碰人人做人人爱| 一本久久知道综合久久| 老熟女毛茸茸浓毛| 国产如狼似虎富婆找强壮黑人| 亚洲图片综合图区20p| 四川丰满妇女毛片四川话| 久久亚洲精品中文字幕| 蜜色欲多人av久久无码| 人妻av无码中文专区久久| 亚洲国产成人乱码| 亚洲欧洲av无码专区| 韩国无码色视频在线观看| 欧美色欧美亚洲高清在线视频| 亚洲精品国产一区二区贰佰信息网| 国产薄丝脚交视频在线观看| 好爽太紧了舒服视频| 中国真实偷乱视频| 久久精品中文字幕无码| 亚洲国产最大av|