在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MRC2 Antibody

  • 中文名稱:
    MRC2兔多克隆抗體
  • 貨號:
    CSB-PA731055ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA731055ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA731055ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MRC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C-type lectin domain family 13 member E antibody; C-type mannose receptor 2 antibody; CD 280 antibody; CD280 antibody; CD280 antigen antibody; CLEC 13E antibody; CLEC13E antibody; ENDO 180 antibody; ENDO180 antibody; Endocytic receptor (macrophage mannose receptor family) antibody; Endocytic receptor 180 antibody; FLJ35911 antibody; KIAA0709 antibody; Macrophage mannose receptor 2 antibody; Mannose receptor C type 2 antibody; MRC 2 antibody; MRC2 antibody; MRC2_HUMAN antibody; UPAR-associated protein antibody; UPARAP antibody; Urokinase plasminogen activator receptor associated protein antibody; Urokinase receptor associated protein antibody; Urokinase receptor-associated protein antibody; Urokinase-type plasminogen activator receptor-associated protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human C-type mannose receptor 2 protein (120-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
  • 基因功能參考文獻:
    1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). PMID: 29061505
    2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family PMID: 27247422
    3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement. PMID: 26527274
    4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. PMID: 26284904
    5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma PMID: 26466547
    6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. PMID: 25381222
    7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. PMID: 25408555
    8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid PMID: 24161566
    9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. PMID: 23433549
    10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. PMID: 22072289
    11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. PMID: 21768090
    12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement PMID: 20845060
    13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion PMID: 20339555
    14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. PMID: 19861500
    15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor PMID: 11903048
    16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes PMID: 12068012
    17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. PMID: 12244146
    18. characterization of the monosaccharide binding sites PMID: 12399458
    19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor. PMID: 12645947
    20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass. PMID: 12952933
    21. Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis PMID: 12972549
    22. Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. PMID: 17189524
    23. To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. PMID: 17974964
    24. By using cell isolates from uPARAP deficient mice, it is demonstrated that uPARAP is a collagen receptor. Thus uPARAP deficient fibroblasts can not internalize collagen and show a reduced adhesion/migration on collagen surfaces PMID: 12668656

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • 數據庫鏈接:

    HGNC: 16875

    OMIM: 612264

    KEGG: hsa:9902

    STRING: 9606.ENSP00000307513

    UniGene: Hs.7835



主站蜘蛛池模板: 熟妇五十路六十路息与子| 九色porny丨国产首页注册| 久久精品中文字幕一区二区三区| 女人被狂躁c到高潮喷水电影| 国产美女自卫慰水免费视频| 无码任你躁久久久久久老妇蜜桃| 综合 欧美 小说 另类 图| 欧美丰满老妇性猛交| 国产对白老熟女正在播放| 国产麻豆精品久久一二三| 一区二区视频传媒有限公司| 午夜视频在线观看免费完整版| 精品人妻va出轨中文字幕| 欧美老熟妇欲乱高清视频| 中文字幕在线观看亚洲日韩| 日本熟妇色高清免费视频| 宅男色影视亚洲人在线| 国产精品美女久久久久av超清| 狠狠躁天天躁中文字幕| 美女裸体自慰在线观看| 国产日韩欧美久久久精品图片| 国产专区一线二线三线码| 亚洲精品久久久久中文字幕m男 | 国产日韩亚洲大尺度高清 | 国产无遮挡又黄又爽在线视频| 国产裸体歌舞一区二区| 欧美老熟妇乱子伦视频| 国产精品久久久久久亚洲影视| 亚洲人成无码网www动漫| 制服丝袜另类专区制服| 色综合久久蜜芽国产精品| 国产在线一区二区av视频| 欧洲女人性开放免费网站| 好紧好湿好黄的视频| 99精品国产在热久久婷婷| 国产综合有码无码视频在线 | 亚洲综合一区二区三区无码| 成人网站免费大全日韩国产| 男人的天堂av社区在线| 无码专区6080yy国产电影| 用舌头去添高潮无码视频|