在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MRC2 Antibody

  • 中文名稱:
    MRC2兔多克隆抗體
  • 貨號:
    CSB-PA561662
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 293 cells, using MRC2 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRC2 antibody.
    • Immunofluorescence analysis of HepG2 cells, using MRC2 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MRC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human MRC2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
  • 基因功能參考文獻:
    1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). PMID: 29061505
    2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family PMID: 27247422
    3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement. PMID: 26527274
    4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. PMID: 26284904
    5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma PMID: 26466547
    6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. PMID: 25381222
    7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. PMID: 25408555
    8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid PMID: 24161566
    9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. PMID: 23433549
    10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. PMID: 22072289
    11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. PMID: 21768090
    12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement PMID: 20845060
    13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion PMID: 20339555
    14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. PMID: 19861500
    15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor PMID: 11903048
    16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes PMID: 12068012
    17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. PMID: 12244146
    18. characterization of the monosaccharide binding sites PMID: 12399458
    19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor. PMID: 12645947
    20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass. PMID: 12952933
    21. Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis PMID: 12972549
    22. Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. PMID: 17189524
    23. To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. PMID: 17974964
    24. By using cell isolates from uPARAP deficient mice, it is demonstrated that uPARAP is a collagen receptor. Thus uPARAP deficient fibroblasts can not internalize collagen and show a reduced adhesion/migration on collagen surfaces PMID: 12668656

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 16875

    OMIM: 612264

    KEGG: hsa:9902

    STRING: 9606.ENSP00000307513

    UniGene: Hs.7835



主站蜘蛛池模板: 五十路熟女一区二区三区| 亚洲精品成人久久电影网| 在线天堂免费观看.www| 日本中文字幕乱码免费| 国产999精品久久久久久| 窝窝午夜精品一区二区| 无码专区天天躁天天躁在线| 国产欧美在线一区二区三| 久久99精品久久久久久蜜芽| 豆国产95在线 | 亚洲| 国产麻豆成人精品av| av中文无码乱人伦在线观看| 亚洲精品午夜久久久伊人 | 人妻精品国产一区二区| 国产超碰人人模人人爽人人喊| 国产日产欧美最新| 真人性囗交69视频| 欧美黑人与白人精品a片| 日本少妇浓毛bbwbbwbbw| 国产精品无码一区二区三区在| 全黄h全肉边做边吃奶视频| 无码av动漫精品一区二区免费| 久久精品www人人做人人爽| 亚洲综合图色40p| 国产97色在线 | 国产| 国产午夜片无码区在线观看爱情网 | 免费人成黄页在线观看国产| 日韩aⅴ人妻无码一区二区| 中文字幕在线观看亚洲日韩| 中文www天堂| 丰满人妻熟妇乱又仑精品| 久久一日本道色综合久久| 天无日天天射天天视| 2021久久最新国产精品| 亚洲国产成人精品女人久久久| 久久婷婷久久一区二区三区| 国产成人久久av免费看| 人妻av中文系列| 亚洲精品tv久久久久久久久久| 国内精品乱码卡一卡2卡三卡新区| 国精产品一区一区三区免费视频 |