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  4. Human C-type mannose receptor 2(MRC2) ELISA kit

Human C-type mannose receptor 2(MRC2) ELISA kit

  • 中文名稱：
    人C型甘露糖受體2(MRC2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL014784HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人C型甘露糖受體2(MRC2)酶聯(lián)免疫試劑盒（CSB-EL014784HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的MRC2含量。MRC2即甘露糖受體C2型，是一種細(xì)胞表面蛋白。在癌癥等疾病研究中受關(guān)注，它參與細(xì)胞內(nèi)吞、信號傳導(dǎo)等過程。可能促進(jìn)腫瘤細(xì)胞增殖、遷移和侵襲，還與免疫反應(yīng)調(diào)節(jié)相關(guān)，有望成為疾病診斷標(biāo)志物和治療靶點(diǎn)。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，該產(chǎn)品適用于基礎(chǔ)研究領(lǐng)域，如探究纖維化病理機(jī)制、腫瘤相關(guān)基質(zhì)細(xì)胞功能或免疫調(diào)節(jié)過程中MRC2的動態(tài)變化，多樣化的樣本兼容性為體外實(shí)驗(yàn)設(shè)計提供了靈活選擇。通過標(biāo)準(zhǔn)化的實(shí)驗(yàn)流程和優(yōu)化的反應(yīng)體系，能夠穩(wěn)定獲取實(shí)驗(yàn)數(shù)據(jù)，為分子機(jī)制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C-type lectin domain family 13 member E ELISA Kit; C-type mannose receptor 2 ELISA Kit; CD 280 ELISA Kit; CD280 ELISA Kit; CD280 antigen ELISA Kit; CLEC 13E ELISA Kit; CLEC13E ELISA Kit; ENDO 180 ELISA Kit; ENDO180 ELISA Kit; Endocytic receptor (macrophage mannose receptor family) ELISA Kit; Endocytic receptor 180 ELISA Kit; FLJ35911 ELISA Kit; KIAA0709 ELISA Kit; Macrophage mannose receptor 2 ELISA Kit; Mannose receptor C type 2 ELISA Kit; MRC 2 ELISA Kit; MRC2 ELISA Kit; MRC2_HUMAN ELISA Kit; UPAR-associated protein ELISA Kit; UPARAP ELISA Kit; Urokinase plasminogen activator receptor associated protein ELISA Kit; Urokinase receptor associated protein ELISA Kit; Urokinase receptor-associated protein ELISA Kit; Urokinase-type plasminogen activator receptor-associated protein ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MRC2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 85  
    Range % 80-90  
    1:2 Average % 94  
    Range % 88-105  
    1:4 Average % 99  
    Range % 90-110  
    1:8 Average % 94  
    Range % 80-100  
  • 回收率：
    The recovery of human MRC2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 93 80-98  
    EDTA plasma (n=4) 99 92-110  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    10 2.045 1.952 1.999 1.810  
    5 1.612 1.706 1.659 1.470  
    2.5 1.312 1.240 1.276 1.087  
    1.25 0.841 0.839 0.840 0.651  
    0.625 0.650 0.605 0.628 0.439  
    0.312 0.446 0.415 0.431 0.242  
    0.156 0.275 0.269 0.272 0.083  
    0 0.191 0.187 0.189 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
  • 基因功能參考文獻(xiàn)：
    1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2). PMID: 29061505
    2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family PMID: 27247422
    3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement. PMID: 26527274
    4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript. PMID: 26284904
    5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma PMID: 26466547
    6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates. PMID: 25381222
    7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression. PMID: 25408555
    8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid PMID: 24161566
    9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging. PMID: 23433549
    10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. PMID: 22072289
    11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. PMID: 21768090
    12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement PMID: 20845060
    13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion PMID: 20339555
    14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity. PMID: 19861500
    15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor PMID: 11903048
    16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes PMID: 12068012
    17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages. PMID: 12244146
    18. characterization of the monosaccharide binding sites PMID: 12399458
    19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor. PMID: 12645947
    20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass. PMID: 12952933
    21. Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis PMID: 12972549
    22. Data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen. PMID: 17189524
    23. To investigate the consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice; expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, showed enhanced tumor growth. PMID: 17974964
    24. By using cell isolates from uPARAP deficient mice, it is demonstrated that uPARAP is a collagen receptor. Thus uPARAP deficient fibroblasts can not internalize collagen and show a reduced adhesion/migration on collagen surfaces PMID: 12668656

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16875

    OMIM: 612264

    KEGG: hsa:9902

    STRING: 9606.ENSP00000307513

    UniGene: Hs.7835



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