在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MLYCD Antibody

MLYCD Antibody

  • 中文名稱：
    MLYCD兔多克隆抗體
  • 貨號：
    CSB-PA014646GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DCMC_HUMAN antibody; hMCD antibody; Malonyl CoA decarboxylase antibody; Malonyl CoA decarboxylase mitochondrial antibody; Malonyl coenzyme A decarboxylase antibody; Malonyl-CoA decarboxylase antibody; MCD antibody; MGC59795 antibody; mitochondrial antibody; Mlycd antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MLYCD
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
  • 基因功能參考文獻：
    1. To identify the active site of MCD, molecular docking and molecular dynamics simulations were performed to explore the interactions of human mitochondrial MCD (HmMCD) and CoA derivatives. The findings reveal that the active site of HmMCD indeed resides in the prominent groove which resembles that of curacin A. PMID: 26948533
    2. Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course. PMID: 26858006
    3. The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. PMID: 23791943
    4. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase. PMID: 23482565
    5. Our case emphasizes the need for ongoing cardiac disease screening in patients with MCD deficiency and the benefits and limitations of current dietary interventions. PMID: 22778304
    6. This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension PMID: 20702857
    7. Malonyl-CoA decarboxylase deficiency may result from MLYCD mutations that result in protein mistargeting. PMID: 12955715
    8. The concentration of malonyl-CoA is diminished in muscle after physical training, most likely because of PGC-1alpha-mediated increases in MCD expression and activity. PMID: 16434556
    9. analysis of nine novel MLYCD mutations in patients with malonyl-coenzyme A decarboxylase deficiency PMID: 17186413
    10. MCD silencing suppresses lipid uptake and enhances glucose uptake in primary human myotubes. PMID: 18314420
    11. Data suggest that increased expression of malonyl CoA decarboxylase, and the decreased expression of acetyl CoA carboxylase and 5'-AMP activated protein kinase are important regulators of the maturation of fatty acid oxidation in the newborn human heart. PMID: 18614968

    顯示更多

    收起更多

  • 相關疾病：
    Malonyl-CoA decarboxylase deficiency (MLYCD deficiency)
  • 亞細胞定位：
    Cytoplasm. Mitochondrion matrix. Peroxisome. Peroxisome matrix.
  • 組織特異性：
    Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
  • 數據庫鏈接：

    HGNC: 7150

    OMIM: 248360

    KEGG: hsa:23417

    STRING: 9606.ENSP00000262430

    UniGene: Hs.644610



主站蜘蛛池模板： www成人国产高清内射| 乱人伦中文无码视频| 亚洲综合一区二区三区四区五区| 日本va欧美va精品发布| 久久天天躁狠狠躁夜夜躁app| 一二三四社区在线中文视频| 中文字幕乱码亚洲无线三区| 国产人妻精品一区二区三区| 中文字幕av高清片| 国产在线看片免费观看| 亚洲aⅴ天堂av天堂无码| 中文字幕高清免费日韩视频在线| 日本丰满熟妇videossex一| 尤物国产在线精品福利三区| 久久国产欧美成人网站| 久久精品久久久久观看99水蜜桃| 日日噜噜噜夜夜爽爽狠狠视频| 一个色综合国产色综合| 五月丁香六月综合缴情在线| 午夜男女刺激爽爽影院| 色鬼7777久久| 青春草在线视频免费观看| 亚洲精品国产美女久久久| av无码欧洲亚洲电影网| 国产精品露脸国语对白| 精品久久久久久亚洲精品| 性xxxxx欧美极品少妇| 中文无码精品一区二区三区| 婷婷综合另类小说色区 | 成人做爰免费视频免费看| 人妻少妇伦在线麻豆m电影| 蜜臀avwww国产天堂| 久久精品中文字幕| 中文字幕无码专区一va亚洲v专区在线 | 久久午夜私人影院| 国产欧美亚洲日韩图片| 国产精品原创巨作av| 少妇激情av一区二区三区 | 自拍性旺盛老熟女| 中文人妻无码一区二区三区| 色欲av巨乳无码一区二区|