在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MLYCD Antibody

MLYCD Antibody

  • 中文名稱：
    MLYCD兔多克隆抗體
  • 貨號：
    CSB-PA014646GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DCMC_HUMAN antibody; hMCD antibody; Malonyl CoA decarboxylase antibody; Malonyl CoA decarboxylase mitochondrial antibody; Malonyl coenzyme A decarboxylase antibody; Malonyl-CoA decarboxylase antibody; MCD antibody; MGC59795 antibody; mitochondrial antibody; Mlycd antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MLYCD
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
  • 基因功能參考文獻：
    1. To identify the active site of MCD, molecular docking and molecular dynamics simulations were performed to explore the interactions of human mitochondrial MCD (HmMCD) and CoA derivatives. The findings reveal that the active site of HmMCD indeed resides in the prominent groove which resembles that of curacin A. PMID: 26948533
    2. Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course. PMID: 26858006
    3. The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. PMID: 23791943
    4. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase. PMID: 23482565
    5. Our case emphasizes the need for ongoing cardiac disease screening in patients with MCD deficiency and the benefits and limitations of current dietary interventions. PMID: 22778304
    6. This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension PMID: 20702857
    7. Malonyl-CoA decarboxylase deficiency may result from MLYCD mutations that result in protein mistargeting. PMID: 12955715
    8. The concentration of malonyl-CoA is diminished in muscle after physical training, most likely because of PGC-1alpha-mediated increases in MCD expression and activity. PMID: 16434556
    9. analysis of nine novel MLYCD mutations in patients with malonyl-coenzyme A decarboxylase deficiency PMID: 17186413
    10. MCD silencing suppresses lipid uptake and enhances glucose uptake in primary human myotubes. PMID: 18314420
    11. Data suggest that increased expression of malonyl CoA decarboxylase, and the decreased expression of acetyl CoA carboxylase and 5'-AMP activated protein kinase are important regulators of the maturation of fatty acid oxidation in the newborn human heart. PMID: 18614968

    顯示更多

    收起更多

  • 相關疾病：
    Malonyl-CoA decarboxylase deficiency (MLYCD deficiency)
  • 亞細胞定位：
    Cytoplasm. Mitochondrion matrix. Peroxisome. Peroxisome matrix.
  • 組織特異性：
    Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
  • 數據庫鏈接：

    HGNC: 7150

    OMIM: 248360

    KEGG: hsa:23417

    STRING: 9606.ENSP00000262430

    UniGene: Hs.644610



主站蜘蛛池模板： 777亚洲精品乱码久久久久久| 久久综合久久自在自线精品自| 天堂www中文资源| 最近日本免费观看高清视频| 999久久欧美人妻一区二区| 国产精品亚洲综合一区在线观看| 九色精品国产成人综合网站| 粉嫩大学生无套内射无码卡视频 | 少妇人妻中文字幕hd| 少妇高潮喷水正在播放| 国产jk精品白丝av在线观看| 亚欧美日韩香蕉在线播放视频| 欧美人禽杂交狂配免费看| 欧美自拍亚洲综合图区| 亚洲成_人网站图片| 蜜桃视频一区二区三区在线观看 | 天天狠天天透天干天天怕∴| 边添小泬边狠狠躁视频| 久久国产热精品波多野结衣av | 久久精品国产日本波多野结衣| 丰满爆乳一区二区三区| 国内精品视频自在一区| 日产2021免费一区| 久久九九久精品国产免费直播| 国产精品美女久久久久久| 欧美韩中文精品有码视频在线| 玩弄人妻少妇老师美妇厨房| 无码人妻丰满熟妇奶水区码| 丁香五月亚洲综合在线| 色欲视频综合免费天天| 国产亚洲日韩在线a不卡| 日韩一欧美内射在线观看| 97在线精品视频免费| 国内精品无码一区二区三区 | 亚洲欧美日韩国产综合v| 欧美日本特级婬片视频| 久久久亚洲欧洲日产国码aⅴ| 少妇性l交大片毛多| 少妇人妻陈艳和黑人教练| 一个添下面两个吃奶把腿扒开 | 久久人妻av无码中文专区|