在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MLYCD Antibody, Biotin conjugated

MLYCD Antibody, Biotin conjugated

  • 中文名稱：
    MLYCD兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA014646LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MLYCD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DCMC_HUMAN antibody; hMCD antibody; Malonyl CoA decarboxylase antibody; Malonyl CoA decarboxylase mitochondrial antibody; Malonyl coenzyme A decarboxylase antibody; Malonyl-CoA decarboxylase antibody; MCD antibody; MGC59795 antibody; mitochondrial antibody; Mlycd antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Malonyl-CoA decarboxylase, mitochondrial protein (40-493AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
  • 基因功能參考文獻：
    1. To identify the active site of MCD, molecular docking and molecular dynamics simulations were performed to explore the interactions of human mitochondrial MCD (HmMCD) and CoA derivatives. The findings reveal that the active site of HmMCD indeed resides in the prominent groove which resembles that of curacin A. PMID: 26948533
    2. Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course. PMID: 26858006
    3. The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. PMID: 23791943
    4. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase. PMID: 23482565
    5. Our case emphasizes the need for ongoing cardiac disease screening in patients with MCD deficiency and the benefits and limitations of current dietary interventions. PMID: 22778304
    6. This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension PMID: 20702857
    7. Malonyl-CoA decarboxylase deficiency may result from MLYCD mutations that result in protein mistargeting. PMID: 12955715
    8. The concentration of malonyl-CoA is diminished in muscle after physical training, most likely because of PGC-1alpha-mediated increases in MCD expression and activity. PMID: 16434556
    9. analysis of nine novel MLYCD mutations in patients with malonyl-coenzyme A decarboxylase deficiency PMID: 17186413
    10. MCD silencing suppresses lipid uptake and enhances glucose uptake in primary human myotubes. PMID: 18314420
    11. Data suggest that increased expression of malonyl CoA decarboxylase, and the decreased expression of acetyl CoA carboxylase and 5'-AMP activated protein kinase are important regulators of the maturation of fatty acid oxidation in the newborn human heart. PMID: 18614968

    顯示更多

    收起更多

  • 相關疾病：
    Malonyl-CoA decarboxylase deficiency (MLYCD deficiency)
  • 亞細胞定位：
    Cytoplasm. Mitochondrion matrix. Peroxisome. Peroxisome matrix.
  • 組織特異性：
    Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
  • 數據庫鏈接：

    HGNC: 7150

    OMIM: 248360

    KEGG: hsa:23417

    STRING: 9606.ENSP00000262430

    UniGene: Hs.644610



主站蜘蛛池模板： 老司机亚洲精品影院无码| 夜夜夜夜猛噜噜噜噜噜| 国产亚洲精品资源在线26u| 国产性色αv视频免费 | 国产一卡二卡三新区2022| 18禁超污无遮挡无码免费动态图 | 久久综合给合久久狠狠狠88| 一本大道在线观看无码一区| 丰满又黄又爽少妇毛片| 伊人久久精品av一区二区| 国产无遮挡aaa片爽爽| 色情久久久av熟女人妻网站| 丰满的少妇xxxxx人| 99久久精品国产免费| 一本大道东京热无码aⅴ| 日本免费视频| 久久久精品久久久久久96| 亚洲一区二区三区无码av| 亚洲熟妇av一区| 成人aaa片一区国产精品| 欧美熟妇的性裸交| 少妇精品偷拍高潮少妇小说| 亚洲精品久久久久中文字幕二区| 国产激情久久久久久熟女老人av| 亚洲妇女行蜜桃av网网站| 中文字幕无码中文字幕有码a| 97高清国语自产拍| 国产又色又爽又黄又免费软件| 久久久国产99久久国产久麻豆| 中文字幕乱码熟妇五十中出色欲 | 在线偷着国产精选视频| 欧美在线观看免费专区| 国产乱子夫妻xx黑人xyx真爽| 无码人妻久久一区二区三区| 久久综合a∨色老头免费观看| 国产伦精品一区二区三区免.费| 日本最大色倩网站www| 久久久综合九色综合88| 国产日韩欧美亚欧在线观看| 国产偷国产偷亚洲高清app| 无码精品一区二区三区在线|