在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MLYCD Antibody, FITC conjugated

MLYCD Antibody, FITC conjugated

  • 中文名稱(chēng)：
    MLYCD兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA014646LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) MLYCD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DCMC_HUMAN antibody; hMCD antibody; Malonyl CoA decarboxylase antibody; Malonyl CoA decarboxylase mitochondrial antibody; Malonyl coenzyme A decarboxylase antibody; Malonyl-CoA decarboxylase antibody; MCD antibody; MGC59795 antibody; mitochondrial antibody; Mlycd antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Malonyl-CoA decarboxylase, mitochondrial protein (40-493AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
  • 基因功能參考文獻(xiàn)：
    1. To identify the active site of MCD, molecular docking and molecular dynamics simulations were performed to explore the interactions of human mitochondrial MCD (HmMCD) and CoA derivatives. The findings reveal that the active site of HmMCD indeed resides in the prominent groove which resembles that of curacin A. PMID: 26948533
    2. Our result expands the phenotype of malonyl-CoA decarboxylase deficiency and suggests attentions should be paid to the mild form of disorders, for example, malonyl-CoA decarboxylase deficiency, which usually present a severe disease course. PMID: 26858006
    3. The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. PMID: 23791943
    4. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase. PMID: 23482565
    5. Our case emphasizes the need for ongoing cardiac disease screening in patients with MCD deficiency and the benefits and limitations of current dietary interventions. PMID: 22778304
    6. This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension PMID: 20702857
    7. Malonyl-CoA decarboxylase deficiency may result from MLYCD mutations that result in protein mistargeting. PMID: 12955715
    8. The concentration of malonyl-CoA is diminished in muscle after physical training, most likely because of PGC-1alpha-mediated increases in MCD expression and activity. PMID: 16434556
    9. analysis of nine novel MLYCD mutations in patients with malonyl-coenzyme A decarboxylase deficiency PMID: 17186413
    10. MCD silencing suppresses lipid uptake and enhances glucose uptake in primary human myotubes. PMID: 18314420
    11. Data suggest that increased expression of malonyl CoA decarboxylase, and the decreased expression of acetyl CoA carboxylase and 5'-AMP activated protein kinase are important regulators of the maturation of fatty acid oxidation in the newborn human heart. PMID: 18614968

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Malonyl-CoA decarboxylase deficiency (MLYCD deficiency)
  • 亞細(xì)胞定位：
    Cytoplasm. Mitochondrion matrix. Peroxisome. Peroxisome matrix.
  • 組織特異性：
    Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7150

    OMIM: 248360

    KEGG: hsa:23417

    STRING: 9606.ENSP00000262430

    UniGene: Hs.644610



主站蜘蛛池模板： 人妻少妇精品无码专区动漫| 最近中文字幕mv在线视频2018| 男人添女人下部高潮全视频| 精品深夜av无码一区二区老年| 野外少妇愉情中文字幕| 婷婷五月深深久久精品| 小荡货奶真大水多好紧视频| 欧美白人最猛性xxxxx| 色婷婷综合缴情综免费观看| 少妇邻居内射在线| 一区三区不卡高清影视| 亚洲欧美日韩另类丝袜一区| 国产色婷婷亚洲99精品小说| 熟女人妻在线视频| 亚洲日韩性欧美中文字幕| 亚洲色成人一区二区三区| 欧美老妇与禽交| 成人午夜又粗又硬又长| 尹人香蕉久久99天天拍欧美p7| 丁香五月综合久久激情| 老女老肥熟国产在线视频| 奇米影视7777久久精品| 国产在线精品一区二区| 日本一道本高清一区二区| 国产福利免费视频不卡| 欧美黑人又大又粗xxxxx| 忍着娇喘人妻被中出中文字幕 | 国产aⅴ激情无码久久久无码| 天无日天天射天天视| 7777奇米成人狠狠成人影视| 亚洲国产精品嫩草影院| 女人被狂躁c到高潮| 日本亚洲欧美高清专区vr专区| 视频久re精品在线观看| 大地资源中文第三页| 国产尤物av尤物在线看| 亚洲中文字幕无码卡通动漫野外 | 日日橹狠狠爱欧美超碰| 日本道精品一区二区三区| 女女女女女裸体开bbb| 国产成a人亚洲精品无码久久网|